| EC |
1.1.1.201 |
| Accepted name: |
7β-hydroxysteroid dehydrogenase (NADP+) |
| Reaction: |
a 7β-hydroxysteroid + NADP+ = a 7-oxosteroid + NADPH + H+ |
| Other name(s): |
NADP-dependent 7β-hydroxysteroid dehydrogenase; 7β-hydroxysteroid dehydrogenase (NADP) |
| Systematic name: |
7β-hydroxysteroid:NADP+ 7-oxidoreductase |
| Comments: |
Catalyses the oxidation of the 7β-hydroxy group of bile acids such as ursodeoxycholate. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 79393-83-2 |
| References: |
| 1. |
Hirano, S. and Masuda, N. Characterization of NADP-dependent 7β-hydroxysteroid dehydrogenases from Peptostreptococcus productus and Eubacterium aerofaciens. Appl. Environ. Microbiol. 43 (1982) 1057–1063. [PMID: 6954878] |
| 2. |
Macdonald, I.A. and Roach, P.D. Bile induction of 7α- and 7β-hydroxysteroid dehydrogenases in Clostridium absonum. Biochim. Biophys. Acta 665 (1981) 262–269. [DOI] [PMID: 6945134] |
| 3. |
Macdonald, I.A., Rochon, Y.P., Hutchison, D.M. and Holdeman, L.V. Formation of ursodeoxycholic acid from chenodeoxycholic acid by a 7β-hydroxysteroid dehydrogenase-elaborating Eubacterium aerofaciens strain cocultured with 7α-hydroxysteroid dehydrogenase-elaborating organisms. Appl. Environ. Microbiol. 44 (1982) 1187–1195. [PMID: 6758698] |
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| [EC 1.1.1.201 created 1984] |
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