| EC |
1.1.1.184 |
| Accepted name: |
carbonyl reductase (NADPH) |
| Reaction: |
R-CHOH-R′ + NADP+ = R-CO-R′ + NADPH + H+ |
| Other name(s): |
aldehyde reductase 1; prostaglandin 9-ketoreductase; xenobiotic ketone reductase; NADPH-dependent carbonyl reductase; ALR3; carbonyl reductase; nonspecific NADPH-dependent carbonyl reductase; carbonyl reductase (NADPH2) |
| Systematic name: |
secondary-alcohol:NADP+ oxidoreductase |
| Comments: |
Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin and prostaglandins E and F, reducing them to the corresponding alcohol. Si-specific with respect to NADPH [cf. EC 1.1.1.2 alcohol dehydrogenase (NADP+)]. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 89700-36-7 |
| References: |
| 1. |
Ahmed, N.K., Felsted, R.L. and Bachur, N.R. Heterogeneity of anthracycline antibiotic carbonyl reductases in mammalian livers. Biochem. Pharmacol. 27 (1978) 2713–2719. [DOI] [PMID: 31888] |
| 2. |
Lin, Y.M. and Jarabak, J. Isolation of two proteins with 9-ketoprostaglandin reductase and NADP-linked 15-hydroxyprostaglandin dehydrogenase activities and studies on their inhibition. Biochem. Biophys. Res. Commun. 81 (1978) 1227–1234. [DOI] [PMID: 666816] |
| 3. |
Wermuth, B. Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductase. J. Biol. Chem. 256 (1981) 1206–1213. [PMID: 7005231] |
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| [EC 1.1.1.184 created 1983] |
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