The Enzyme Database

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EC 1.1.1.181     
Accepted name: cholest-5-ene-3β,7α-diol 3β-dehydrogenase
Reaction: cholest-5-ene-3β,7α-diol + NAD+ = 7α-hydroxycholest-4-en-3-one + NADH + H+
For diagram of cholesterol catabolism (rings A, B and C), click here
Other name(s): 3β-hydroxy-Δ5-C27-steroid oxidoreductase (ambiguous)
Systematic name: cholest-5-ene-3β,7α-diol:NAD+ 3-oxidoreductase
Comments: Highly specific for 3β,7α-dihydroxy-C27-steroids with Δ5-double bond.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 56626-16-5
References:
1.  Wikvall, K. Purification and properties of a 3β-hydroxy-Δ5-C27-steroid oxidoreductase from rabbit liver microsomes. J. Biol. Chem. 256 (1981) 3376–3380. [PMID: 6937465]
2.  Schwarz, M., Wright, A.C., Davis, D.L., Nazer, H., Bjorkhem, I. and Russell, D.W. The bile acid synthetic gene 3β-hydroxy-Δ5-C27-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis. J. Clin. Invest. 106 (2000) 1175–1184. [PMID: 11067870]
[EC 1.1.1.181 created 1983]
 
 


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