Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB)

Proposed Changes to the Enzyme List

The entries below are proposed additions and amendments to the Enzyme Nomenclature list. They were prepared for the NC-IUBMB by Kristian Axelsen, Ron Caspi, Ture Damhus, Shinya Fushinobu, Julia Hauenstein, Antje Jäde, Ingrid Keseler, Masaaki Kotera, Andrew McDonald, Gerry Moss, Ida Schomburg and Keith Tipton. Comments and suggestions on these draft entries should be sent to Dr Andrew McDonald (Department of Biochemistry, Trinity College Dublin, Dublin 2, Ireland). The date on which an enzyme will be made official is appended after the EC number. To prevent confusion please do not quote new EC numbers until they are incorporated into the main list.

An asterisk before 'EC' indicates that this is an amendment to an existing enzyme rather than a new enzyme entry.

EC 1.3.8.17 dehydro coenzyme F₄₂₀ reductase
EC 1.3.8.17 dehydro coenzyme F₄₂₀ reductase
EC 1.3.8.17 dehydro coenzyme F₄₂₀ reductase

1.3.8.17

Accepted name:

dehydro coenzyme F₄₂₀ reductase

Reaction:

oxidized coenzyme F₄₂₀-0 + FMN = dehydro coenzyme F₄₂₀-0 + FMNH₂

Glossary:

dehydro coenzyme F₄₂₀-0 = 2-{[5-deoxy-5-(8-hydroxy-2,4-dioxopyrimidino[4,5-b]quinolin-10(2H)-yl)-L-ribityloxy]hydroxyphosphoryloxy}prop-2-enoate

Other name(s):

fbiB (gene name)

Systematic name:

oxidized coenzyme F₄₂₀-0:FMN oxidoreductase

Comments:

This enzyme is involved in the biosynthesis of factor 420 (coenzyme F₄₂₀), a redox-active compound found in all methanogenic archaea, as well as some eubacteria. In some eubacteria the enzyme is multifunctional, also catalysing the activities of EC 6.3.2.31, coenzyme F₄₂₀-0:L-glutamate ligase, and EC 6.3.2.34, coenzyme F₄₂₀-1:γ-L-glutamate ligase.

Links to other databases:

BRENDA, EXPASY, KEGG, PDB

References:

Bashiri, G., Antoney, J., Jirgis, E.NM., Shah, M.V., Ney, B., Copp, J., Stuteley, S.M., Sreebhavan, S., Palmer, B., Middleditch, M., Tokuriki, N., Greening, C., Scott, C., Baker, E.N. and Jackson, C.J. A revised biosynthetic pathway for the cofactor F₄₂₀ in prokaryotes. Nat. Commun. 10:1558 (2019). [DOI] [PMID: 30952857]

[EC 1.3.8.17 created 2021]

Proposed Changes to the Enzyme List

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