The mechanism below rationalizes the reaction mechanism of the formation of the sulfenic acid, see Wood, Z.A., Schröder, E., Harris, J.R. and Poole, L.B. Structure, mechanism and regulation of peroxiredoxins. Trends Biochem. Sci. 28 (2003) 32-40. [PMID: 12517450]
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It is possible that a base B: in the protein assists the cysteine residue to lose H+, and that its protonated form assists the RO- group to leave the peroxide. The S- form of the cysteine may be stabilized by an arginine residue, whose guanidino group is shown.
EC 22.214.171.124 peroxiredoxin (mechanism)