|
Your query returned 15 entries. Printable version
EC | 1.10.99.3 | ||||||||||||||
Transferred entry: | violaxanthin de-epoxidase. Now classified as EC 1.23.5.1, violaxanthin de-epoxidase. | ||||||||||||||
EC | 1.13.11.51 | ||||||||||||||
Accepted name: | 9-cis-epoxycarotenoid dioxygenase | ||||||||||||||
Reaction: | (1) a 9-cis-epoxycarotenoid + O2 = 2-cis,4-trans-xanthoxin + a 12′-apo-carotenal (2) 9-cis-violaxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12′-apo-β-caroten-12′-al (3) 9′-cis-neoxanthin + O2 = 2-cis,4-trans-xanthoxin + (3S,5R,6R)-5,6-dihydroxy-6,7-didehydro-5,6-dihydro-12′-apo-β-caroten-12′-al |
||||||||||||||
For diagram of abscisic-acid biosynthesis, click here | |||||||||||||||
Other name(s): | nine-cis-epoxycarotenoid dioxygenase; NCED; AtNCED3; PvNCED1; VP14 | ||||||||||||||
Systematic name: | 9-cis-epoxycarotenoid 11,12-dioxygenase | ||||||||||||||
Comments: | Requires iron(II). Acts on 9-cis-violaxanthin and 9′-cis-neoxanthin but not on the all-trans isomers [2,3]. In vitro, it will cleave 9-cis-zeaxanthin. Catalyses the first step of abscisic-acid biosynthesis from carotenoids in chloroplasts, in response to water stress. The other enzymes involved in the abscisic-acid biosynthesis pathway are EC 1.1.1.288 (xanthoxin dehydrogenase), EC 1.2.3.14 (abscisic-aldehyde oxidase) and EC 1.14.13.93 [(+)-abscisic acid 8′-hydroxylase]. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 199877-10-6 | ||||||||||||||
References: |
| ||||||||||||||
EC | 1.13.11.65 | ||||||||||||||
Accepted name: | carotenoid isomerooxygenase | ||||||||||||||
Reaction: | zeaxanthin + O2 = (3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal | ||||||||||||||
For diagram of zeaxanthin biosynthesis, click here | |||||||||||||||
Other name(s): | ninaB (gene name) | ||||||||||||||
Systematic name: | zeaxanthin:oxygen 15,15′-oxidoreductase (bond-cleaving, cis-isomerizing) | ||||||||||||||
Comments: | The enzyme, characterized from the moth Galleria mellonella and the fruit fly Drosophila melanogaster, is involved in the synthesis of retinal from dietary caroteoids in insects. The enzyme accepts different all-trans carotenoids, including β-carotene, α-carotene and lutein, and catalyses the symmetrical cleavage of the carotenoid and the simultaneous isomerization of only one of the products to a cis configuration. When the substrate is hydroxylated only in one side (as in cryptoxanthin), the enzyme preferentially isomerizes the hydroxylated part of the molecule. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||||
References: |
| ||||||||||||||
EC | 1.13.11.84 | ||||||||||||||
Accepted name: | crocetin dialdehyde synthase | ||||||||||||||
Reaction: | zeaxanthin + 2 O2 = crocetin dialdehyde + 2 3β-hydroxy-β-cyclocitral (overall reaction) (1a) zeaxanthin + O2 = 3β-hydroxy-8′-apo-β-carotenal + 3β-hydroxy-β-cyclocitral (1b) 3β-hydroxy-8′-apo-β-carotenal + O2 = crocetin dialdehyde + 3β-hydroxy-β-cyclocitral |
||||||||||||||
Glossary: | crocetin dialdehyde = 8,8′-diapocarotene-8,8′-dial zeaxanthin = (3R,3′R)-β,β-carotene-3,3′-diol 3β-hydroxy-β-cyclocitral = (4R)-4-hydroxy-2,6,6-trimethylcyclohex-1-en-1-carboxaldehyde |
||||||||||||||
Other name(s): | CCD2; zeaxanthin 7,8-dioxygenase | ||||||||||||||
Systematic name: | zeaxanthin:oxygen 7′,8′-oxidoreductase (bond-cleaving) | ||||||||||||||
Comments: | The enzyme, characterized from the plant Crocus sativus (saffron), acts twice, cleaving 3β-hydroxy-β-cyclocitral off each 3-hydroxy end group. It is part of the zeaxanthin degradation pathway in that plant, leading to the different compounds that impart the color, flavor and aroma of the saffron spice. The enzyme can similarly cleave the 7-8 double bond of other carotenoids with a 3-hydroxy-β-carotenoid end group. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||||
References: |
| ||||||||||||||
EC | 1.14.13.90 | ||||||||||||||
Transferred entry: | zeaxanthin epoxidase. Now EC 1.14.15.21, zeaxanthin epoxidase | ||||||||||||||
EC | 1.14.13.129 | ||||||||||||||
Transferred entry: | β-carotene 3-hydroxylase. Now EC 1.14.15.24, β-carotene 3-hydroxylase. | ||||||||||||||
EC | 1.14.13.164 | ||||||||||||||
Transferred entry: | carotenoid isomerooxygenase. The enzyme was discovered at the public-review stage to have been misclassified and so was withdrawn. See EC 1.13.11.65, carotenoid isomerooxygenase | ||||||||||||||
EC | 1.14.15.21 | ||||||||||||||
Accepted name: | zeaxanthin epoxidase | ||||||||||||||
Reaction: | zeaxanthin + 4 reduced ferredoxin [iron-sulfur] cluster + 4 H+ + 2 O2 = violaxanthin + 4 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O (overall reaction) (1a) zeaxanthin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = antheraxanthin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O (1b) antheraxanthin + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = violaxanthin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O |
||||||||||||||
For diagram of the xanthophyll cycle, click here | |||||||||||||||
Other name(s): | Zea-epoxidase | ||||||||||||||
Systematic name: | zeaxanthin,reduced ferredoxin:oxygen oxidoreductase | ||||||||||||||
Comments: | A flavoprotein (FAD) that is active under conditions of low light. Along with EC 1.23.5.1, violaxanthin de-epoxidase, this enzyme forms part of the xanthophyll (or violaxanthin) cycle, which is involved in protecting the plant against damage by excess light. It will also epoxidize lutein in some higher-plant species. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 149718-34-3 | ||||||||||||||
References: |
| ||||||||||||||
EC | 1.14.15.24 | ||||||||||||||
Accepted name: | β-carotene 3-hydroxylase | ||||||||||||||
Reaction: | β-carotene + 4 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + 2 O2 = zeaxanthin + 4 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O
(overall reaction) (1a) β-carotene + 2 reduced ferredoxin [iron-sulfur] cluster + H+ + O2 = β-cryptoxanthin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O (1b) β-cryptoxanthin + 2 reduced ferredoxin [iron-sulfur] cluster + H+ + O2 = zeaxanthin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O |
||||||||||||||
For diagram of lutein biosynthesis, click here and for diagram of zeaxanthin biosynthesis, click here | |||||||||||||||
Other name(s): | β-carotene 3,3′-monooxygenase; CrtZ | ||||||||||||||
Systematic name: | β-carotene,reduced ferredoxin [iron-sulfur] cluster:oxygen 3-oxidoreductase | ||||||||||||||
Comments: | Requires ferredoxin and iron(II). Also acts on other carotenoids with a β-end group. In some species canthaxanthin is the preferred substrate. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||||
References: |
| ||||||||||||||
EC | 1.14.99.42 | ||||||||||||||
Transferred entry: | zeaxanthin 7,8-dioxygenase. Now EC 1.13.11.84, crocetin dialdehyde synthase | ||||||||||||||
EC | 1.14.99.63 | ||||||||||||||
Accepted name: | β-carotene 4-ketolase | ||||||||||||||
Reaction: | (1) β-carotene + 2 reduced acceptor + 2 O2 = echinenone + 2 acceptor + 3 H2O (2) echinenone + 2 reduced acceptor + 2 O2 = canthaxanthin + 2 acceptor + 3 H2O |
||||||||||||||
For diagram of canthaxanthin biosynthesis, click here | |||||||||||||||
Glossary: | echinenone = β,β-caroten-4-one canthaxanthin = β,β-carotene-4,4′-dione zeaxanthin = β,β-carotene-3,3′-diol astaxanthin = 3,3′-dihydroxy-β,β-carotene-4,4′-dione |
||||||||||||||
Other name(s): | BKT (ambiguous); β-C-4 oxygenase; β-carotene ketolase; crtS (gene name); crtW (gene name) | ||||||||||||||
Systematic name: | β-carotene,donor:oxygen oxidoreductase (echinenone-forming) | ||||||||||||||
Comments: | The enzyme, studied from algae, plants, fungi, and bacteria, adds an oxo group at position 4 of a carotenoid β ring. It is involved in the biosynthesis of carotenoids such as astaxanthin and flexixanthin. The enzyme does not act on β rings that are hydroxylated at position 3, such as in zeaxanthin (cf. EC 1.14.99.64, zeaxanthin 4-ketolase). The enzyme from the yeast Xanthophyllomyces dendrorhous is bifuntional and also catalyses the activity of EC 1.14.15.24, β-carotene 3-hydroxylase. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||||
References: |
| ||||||||||||||
EC | 1.14.99.64 | ||||||||||||||
Accepted name: | zeaxanthin 4-ketolase | ||||||||||||||
Reaction: | (1) zeaxanthin + 2 reduced acceptor + 2 O2 = adonixanthin + 2 acceptor + 3 H2O (2) adonixanthin + 2 reduced acceptor + 2 O2 = (3S,3′S)-astaxanthin + 2 acceptor + 3 H2O |
||||||||||||||
Glossary: | zeaxanthin = β,β-carotene-3,3′-diol adonixanthin = 3,3′-dihydroxy-β,β-carotene-4-one (3S,3′S)-astaxanthin = (3S,3′S)-3,3′-dihydroxy-β,β-carotene-4,4′-dione |
||||||||||||||
Other name(s): | BKT (ambiguous); crtW148 (gene name) | ||||||||||||||
Systematic name: | zeaxanthin,donor:oxygen oxidoreductase (adonixanthin-forming) | ||||||||||||||
Comments: | The enzyme has a similar activity to that of EC 1.14.99.63, β-carotene 4-ketolase, but unlike that enzyme is able to also act on zeaxanthin. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||||
References: |
| ||||||||||||||
EC | 1.23.5.1 | ||||||||||||||
Accepted name: | violaxanthin de-epoxidase | ||||||||||||||
Reaction: | violaxanthin + 2 L-ascorbate = zeaxanthin + 2 L-dehydroascorbate + 2 H2O (overall reaction) (1a) violaxanthin + L-ascorbate = antheraxanthin + L-dehydroascorbate + H2O (1b) antheraxanthin + L-ascorbate = zeaxanthin + L-dehydroascorbate + H2O |
||||||||||||||
For diagram of the xanthophyll cycle, click here | |||||||||||||||
Glossary: | violaxanthin = (3S,3′S,5R,5′R,6S,6′S)-5,6:5′,6′-diepoxy-5,5′,6,6′-tetrahydro-β,β-carotene-3,3′-diol antheraxanthin = (3R,3′S,5′R,6′S)-5′,6′-epoxy-5′,6′-dihydro-β,β-carotene-3,3′-diol zeaxanthin = (3R,3′R)-β,β-carotene-3,3′-diol |
||||||||||||||
Other name(s): | VDE | ||||||||||||||
Systematic name: | violaxanthin:ascorbate oxidoreductase | ||||||||||||||
Comments: | Along with EC 1.14.15.21, zeaxanthin epoxidase, this enzyme forms part of the xanthophyll (or violaxanthin) cycle for controlling the concentration of zeaxanthin in chloroplasts. It is activated by a low pH of the thylakoid lumen (produced by high light intensity). Zeaxanthin induces the dissipation of excitation energy in the chlorophyll of the light-harvesting protein complex of photosystem II. In higher plants the enzyme reacts with all-trans-diepoxides, such as violaxanthin, and all-trans-monoepoxides, but in the alga Mantoniella squamata, only the diepoxides are good substrates. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 57534-73-3 | ||||||||||||||
References: |
| ||||||||||||||
EC | 2.4.1.276 | ||||||||||||||
Accepted name: | zeaxanthin glucosyltransferase | ||||||||||||||
Reaction: | 2 UDP-glucose + zeaxanthin = 2 UDP + zeaxanthin bis(β-D-glucoside) | ||||||||||||||
For diagram of zeaxanthin biosynthesis, click here | |||||||||||||||
Other name(s): | crtX (gene name) | ||||||||||||||
Systematic name: | UDP-glucose:zeaxanthin β-D-glucosyltransferase | ||||||||||||||
Comments: | The reaction proceeds in two steps with the monoglucoside as an intermediate. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||||
References: |
| ||||||||||||||
EC | 5.3.3.22 | ||||||||||||||
Accepted name: | lutein isomerase | ||||||||||||||
Reaction: | lutein = meso-zeaxanthin | ||||||||||||||
For diagram of lutein biosynthesis, click here | |||||||||||||||
Glossary: | lutein = (3R,3′R)-dihydroxy-α-carotene meso-zeaxanthin = (3R,3′S)-β,β-carotene-3,3′-diol |
||||||||||||||
Other name(s): | RPE65 (gene name); meso-zeaxanthin isomerase | ||||||||||||||
Systematic name: | lutein Δ4-Δ5-isomerase | ||||||||||||||
Comments: | The enzyme is found in the retinal pigment epithelium (RPE) of vertebrates. It also has the activity of EC 3.1.1.64, retinoid isomerohydrolase. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||||
References: |
| ||||||||||||||