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Your query returned 3 entries. Printable version
EC | 1.14.13.126 | ||||||||||||||
Transferred entry: | vitamin D3 24-hydroxylase. Now EC 1.14.15.16, vitamin D3 24-hydroxylase | ||||||||||||||
EC | 1.14.15.16 | ||||||||||||||
Accepted name: | vitamin D3 24-hydroxylase | ||||||||||||||
Reaction: | (1) calcitriol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitetrol + 2 oxidized adrenodoxin + H2O (2) calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = secalciferol + 2 oxidized adrenodoxin + H2O |
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For diagram of calciferol biosynthesis, click here | |||||||||||||||
Glossary: | calcidiol = 25-hydroxyvitamin D3 = (3S,5Z,7E)-9,10-seco-5,7,10(19)-cholestatriene-3,25-diol calcitriol = 1α,25-dihydroxyvitamin D3 = (1S,3R,5Z,7E)-9,10-seco-5,7,10(19)-cholestatriene-1,3,25-triol calcitetrol = 1α,24R,25-trihydroxyvitamin D3 = (1S,3R,5Z,7E,24R)-9,10-seco-5,7,10(19)-cholestatriene-1,3,24,25-tetrol secalciferol = (24R)-24,25-dihydroxycalciol = 24R,25-dihydroxyvitamin D3 = (3R,5Z,7E,24R)-9,10-seco-5,7,10(19)-cholestatriene-3,24,25-triol |
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Other name(s): | CYP24A1 | ||||||||||||||
Systematic name: | calcitriol,adrenodoxin:oxygen oxidoreductase (24-hydroxylating) | ||||||||||||||
Comments: | This mitochondrial cytochrome P-450 enzyme requires adrenodoxin. The enzyme can perform up to 6 rounds of hydroxylation of the substrate calcitriol leading to calcitroic acid. The human enzyme also shows 23-hydroxylating activity leading to 1,25 dihydroxyvitamin D3-26,23-lactone as end product while the mouse and rat enzymes do not. The initial source of the electrons is NADPH, which transfers the electrons to the adrenodoxin via EC 1.18.1.6, adrenodoxin-NADP+ reductase. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||||
References: |
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EC | 1.14.15.18 | ||||||||||||||
Accepted name: | calcidiol 1-monooxygenase | ||||||||||||||
Reaction: | (1) calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O (2) secalciferol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitetrol + 2 oxidized adrenodoxin + H2O |
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For diagram of calciferol biosynthesis, click here | |||||||||||||||
Glossary: | calcidiol = 25-hydroxyvitamin D3 = (3S,5Z,7E)-9,10-seco-5,7,10(19)-cholestatriene-3,25-diol calcitriol = 1α,25-dihydroxyvitamin D3 = (1S,3R,5Z,7E)-9,10-seco-5,7,10(19)-cholestatriene-1,3,25-triol secalciferol = (24R),25-dihydroxyvitamin D3 = (3S,5Z,7E,24R)-9,10-secocholesta-5,7,10-triene-3,24,25-triol calcitetrol = 1α,(24R),25-dihydroxyvitamin D3 = (1S,3R,5Z,7E,24R,25)-9,10-secocholesta-5,7,10(19)-triene-1,3,24,25-tetrol |
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Other name(s): | 25-hydroxycholecalciferol 1-hydroxylase; 25-hydroxycholecalciferol 1-monooxygenase; 1-hydroxylase-25-hydroxyvitamin D3; 25-hydroxy D3-1α-hydroxylase; 25-hydroxycholecalciferol 1α-hydroxylase; 25-hydroxyvitamin D3 1α-hydroxylase | ||||||||||||||
Systematic name: | calcidiol,adrenodoxin:oxygen oxidoreductase (1-hydroxylating) | ||||||||||||||
Comments: | A P-450 (heme-thiolate) enzyme found in mammals. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9081-36-1 | ||||||||||||||
References: |
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