EC
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1.14.13.110
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Transferred entry: | geranylgeraniol 18-hydroxylase. Now EC 1.14.14.146, geranylgeraniol 18-hydroxylase
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[EC 1.14.13.110 created 2009, deleted 2018] |
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EC |
1.14.14.146 |
Accepted name: |
geranylgeraniol 18-hydroxylase |
Reaction: |
geranylgeraniol + [reduced NADPH—hemoprotein reductase] + O2 = 18-hydroxygeranylgeraniol + [oxidized NADPH—hemoprotein reductase] + H2O |
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For diagram of acyclic diterpenoid biosynthesis, click here |
Glossary: |
plaunotol = 18-hydroxygeranylgeraniol |
Other name(s): |
GGOH-18-hydroxylase |
Systematic name: |
geranylgeraniol,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (18-hydroxylating) |
Comments: |
A cytochrome P-450 (heme-thiolate) protein isolated from the plant Croton sublyratus. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Tansakul, P. and De-Eknamkul, W. Geranylgeraniol-18-hydroxylase: the last enzyme in the plaunotol biosynthetic pathway in Croton sublyratus. Phytochemistry 47 (1998) 1241–1246. |
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[EC 1.14.14.146 created 2009 as EC 1.14.13.110, transferred 2018 to EC 1.14.14.146] |
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EC |
3.1.7.5 |
Accepted name: |
geranylgeranyl diphosphate diphosphatase |
Reaction: |
geranylgeranyl diphosphate + H2O = geranylgeraniol + diphosphate |
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For diagram of acyclic diterpenoid biosynthesis, click here |
Glossary: |
plaunotol = 18-hydroxygeranylgeraniol |
Other name(s): |
geranylgeranyl diphosphate phosphatase |
Systematic name: |
geranyl-diphosphate diphosphohydrolase |
Comments: |
Involved in the biosynthesis of plaunotol. There are two isoenzymes with different ion requirements. Neither require Mg2+ but in addition PII is inhibited by Zn2+, Mn2+ and Co2+. It is not known which isoenzyme is involved in plaunotol biosynthesis. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Nualkaew, N., De-Eknamkul, W., Kutchan, T.M. and Zenk, M.H. Membrane-bound geranylgeranyl diphosphate phosphatases: purification and characterization from Croton stellatopilosus leaves. Phytochemistry 67 (2006) 1613–1620. [DOI] [PMID: 16445953] |
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[EC 3.1.7.5 created 2009] |
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