EC |
4.2.1.174 |
Accepted name: |
peregrinol diphosphate synthase |
Reaction: |
peregrinol diphosphate = geranylgeranyl diphosphate + H2O |
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For diagram of hydroxylabdenyl diphosphate derived diterpenoids, click here |
Glossary: |
peregrinol diphosphate = (13E)-9-hydroxy-8α-labda-13-en-15-yl diphosphate |
Other name(s): |
MvCPS1 |
Systematic name: |
geranylgeranyl-diphosphate hydro-lyase (peregrinol-diphosphate-forming) |
Comments: |
Isolated from the plant Marrubium vulgare (white horehound). Involved in marrubiin biosynthesis. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Zerbe, P., Chiang, A., Dullat, H., O'Neil-Johnson, M., Starks, C., Hamberger, B. and Bohlmann, J. Diterpene synthases of the biosynthetic system of medicinally active diterpenoids in Marrubium vulgare. Plant J. 79 (2014) 914–927. [DOI] [PMID: 24990389] |
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[EC 4.2.1.174 created 2017] |
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EC |
4.2.3.189 |
Accepted name: |
9,13-epoxylabd-14-ene synthase |
Reaction: |
peregrinol diphosphate = (13R)-9,13-epoxylabd-14-ene + diphosphate |
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For diagram of hydroxylabdenyl diphosphate derived diterpenoids, click here |
Glossary: |
peregrinol diphosphate = (13E)-9-hydroxy-8α-labd-13-en-15-yl diphosphate |
Other name(s): |
ELS (gene name); TPS2 (gene name) (ambiguous); peregrinol-diphosphate diphosphate-lyase (9,13-epoxylabd-14-ene-forming) |
Systematic name: |
peregrinol-diphosphate diphosphate-lyase [(13R)-9,13-epoxylabd-14-ene-forming] |
Comments: |
Isolated from the plants Marrubium vulgare (white horehound) and Vitex agnus-castus (chaste tree). Involved in marrubiin biosynthesis. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Zerbe, P., Chiang, A., Dullat, H., O'Neil-Johnson, M., Starks, C., Hamberger, B. and Bohlmann, J. Diterpene synthases of the biosynthetic system of medicinally active diterpenoids in Marrubium vulgare. Plant J. 79 (2014) 914–927. [DOI] [PMID: 24990389] |
2. |
Heskes, A.M., Sundram, T.CM., Boughton, B.A., Jensen, N.B., Hansen, N.L., Crocoll, C., Cozzi, F., Rasmussen, S., Hamberger, B., Hamberger, B., Staerk, D., Møller, B.L. and Pateraki, I. Biosynthesis of bioactive diterpenoids in the medicinal plant Vitex agnus-castus. Plant J. 93 (2018) 943–958. [PMID: 29315936] |
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[EC 4.2.3.189 created 2017] |
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