EC |
2.3.1.270 |
Accepted name: |
lyso-ornithine lipid O-acyltransferase |
Reaction: |
a lyso-ornithine lipid + an acyl-[acyl-carrier protein] = an ornithine lipid + a holo-[acyl-carrier protein] |
Glossary: |
a lyso-ornithine lipid = an Nα-[(3R)-3-hydroxyacyl]-L-ornithine
an ornithine lipid = an Nα-[(3R)-3-(acyloxy)acyl]-L-ornithine |
Other name(s): |
olsA (gene name) |
Systematic name: |
Nα-[(3R)-hydroxy-acyl]-L-ornithine O-acyltransferase |
Comments: |
This bacterial enzyme catalyses the second step in the formation of ornithine lipids. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Weissenmayer, B., Gao, J.L., Lopez-Lara, I.M. and Geiger, O. Identification of a gene required for the biosynthesis of ornithine-derived lipids. Mol. Microbiol. 45 (2002) 721–733. [PMID: 12139618] |
2. |
Aygun-Sunar, S., Bilaloglu, R., Goldfine, H. and Daldal, F. Rhodobacter capsulatus OlsA is a bifunctional enzyme active in both ornithine lipid and phosphatidic acid biosynthesis. J. Bacteriol. 189 (2007) 8564–8574. [PMID: 17921310] |
3. |
Lewenza, S., Falsafi, R., Bains, M., Rohs, P., Stupak, J., Sprott, G.D. and Hancock, R.E. The olsA gene mediates the synthesis of an ornithine lipid in Pseudomonas aeruginosa during growth under phosphate-limiting conditions, but is not involved in antimicrobial peptide susceptibility. FEMS Microbiol. Lett. 320 (2011) 95–102. [DOI] [PMID: 21535098] |
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[EC 2.3.1.270 created 2018] |
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EC |
2.3.2.30 |
Accepted name: |
L-ornithine Nα-acyltransferase |
Reaction: |
L-ornithine + a (3R)-3-hydroxyacyl-[acyl-carrier protein] = a lyso-ornithine lipid + a holo-[acyl-carrier protein] |
Glossary: |
a lyso-ornithine lipid = an Nα-[(3R)-hydroxy-acyl]-L-ornithine |
Other name(s): |
olsB (gene name) |
Systematic name: |
L-ornithine Nα-(3R)-3-hydroxy-acyltransferase |
Comments: |
The enzyme, found in bacteria, catalyses the first step in the biosynthesis of ornithine lipids. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Gao, J.L., Weissenmayer, B., Taylor, A.M., Thomas-Oates, J., Lopez-Lara, I.M. and Geiger, O. Identification of a gene required for the formation of lyso-ornithine lipid, an intermediate in the biosynthesis of ornithine-containing lipids. Mol. Microbiol. 53 (2004) 1757–1770. [DOI] [PMID: 15341653] |
2. |
Vences-Guzman, M.A., Guan, Z., Bermudez-Barrientos, J.R., Geiger, O. and Sohlenkamp, C. Agrobacteria lacking ornithine lipids induce more rapid tumour formation. Environ. Microbiol. 15 (2013) 895–906. [DOI] [PMID: 22958119] |
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[EC 2.3.2.30 created 2017] |
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