|
Your query returned 7 entries. Printable version
EC | 2.7.1.68 | ||||||||||
Accepted name: | 1-phosphatidylinositol-4-phosphate 5-kinase | ||||||||||
Reaction: | ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | ||||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism (part 2), click here | |||||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol = PtdIns 1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P 1-phosphatidyl-1D-myo-inositol 4-phosphate = PtdIns4P 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate = PtdIns(3,4)P2 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = PtdIns(4,5)P2 |
||||||||||
Other name(s): | diphosphoinositide kinase; PIP kinase; phosphatidylinositol 4-phosphate kinase; phosphatidylinositol-4-phosphate 5-kinase; type I PIP kinase | ||||||||||
Systematic name: | ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase | ||||||||||
Comments: | This enzyme can also phosphorylate PtdIns3P in the 4-position, and PtdIns, PtdIns3P and PtdIns(3,4)P2 in the 5-position in vitro, but to a lesser extent. The last of these reactions occurs in vivo and is physiologically relevant. Three different isoforms are known. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 104645-76-3 | ||||||||||
References: |
| ||||||||||
EC | 2.7.1.153 | ||||||||||
Accepted name: | phosphatidylinositol-4,5-bisphosphate 3-kinase | ||||||||||
Reaction: | ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate | ||||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism (part 2), click here | |||||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol = PtdIns 1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P 1-phosphatidyl-1D-myo-inositol 4-phosphate = PtdIns4P 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate = PtdIns(3,4)P2 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = PtdIns(4,5)P2 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate = PtdIns(3,4,5)P3 |
||||||||||
Other name(s): | type I phosphoinositide 3-kinase | ||||||||||
Systematic name: | ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase | ||||||||||
Comments: | This enzyme also catalyses the phosphorylation of PtdIns4P to PtdIns(3,4)P2, and of PtdIns to PtdIns3P. Four mammalian isoforms are known to exist. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 103843-30-7 | ||||||||||
References: |
| ||||||||||
EC | 2.7.1.154 | ||||||||||
Accepted name: | phosphatidylinositol-4-phosphate 3-kinase | ||||||||||
Reaction: | ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate | ||||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism, click here | |||||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol = PtdIns 1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P 1-phosphatidyl-1D-myo-inositol 4-phosphate = PtdIns4P 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate = PtdIns(3,4)P2 |
||||||||||
Other name(s): | type II phosphoinositide 3-kinase; C2-domain-containing phosphoinositide 3-kinase; phosphoinositide 3-kinase | ||||||||||
Systematic name: | ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase | ||||||||||
Comments: | This enzyme also phosphorylates PtdIns to PtdIns3P. Three mammalian isoforms have been found to date. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 141176-94-5 | ||||||||||
References: |
| ||||||||||
EC | 3.1.3.57 | ||||||||||
Accepted name: | inositol-1,4-bisphosphate 1-phosphatase | ||||||||||
Reaction: | 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate | ||||||||||
For diagram of myo-inositol-phosphate biosynthesis, click here | |||||||||||
Other name(s): | inositol-polyphosphate 1-phosphatase | ||||||||||
Systematic name: | 1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase | ||||||||||
Comments: | The enzyme acts on inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate (forming inositol 3,4-bisphosphate) with similar Vmax values for both substrates, but with a five-times higher affinity for the bisphosphate. Does not act on inositol 1-phosphate, inositol 1,4,5-trisphosphate or inositol 1,3,4,5-tetrakisphosphate. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 111070-17-8, 111694-13-4 | ||||||||||
References: |
| ||||||||||
EC | 3.1.3.66 | ||||||||||
Accepted name: | phosphatidylinositol-3,4-bisphosphate 4-phosphatase | ||||||||||
Reaction: | 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate | ||||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism, click here | |||||||||||
Glossary: | inositol 3-phosphate = Ins-3-P inositol 1,3-bisphosphate = Ins(1,3)P2 inositol 3,4-bisphosphate = Ins(3,4)P2 inositol 1,3,4-trisphosphate = Ins(1,3,4)P3 1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P 1-phosphatidyl-1D-myo-inositol 4-phosphate = PtdIns4P |
||||||||||
Other name(s): | inositol-3,4-bisphosphate 4-phosphatase; D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase; phosphoinositide 4-phosphatase; inositol polyphosphate 4-phosphatase; inositol polyphosphate 4-phosphatase type II | ||||||||||
Systematic name: | 1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase | ||||||||||
Comments: | Mg2+-independent. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3,4)P3 to Ins(1,3)P2. It also converts Ins(3,4)P2 into Ins-3-P. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 123644-80-4 | ||||||||||
References: |
| ||||||||||
EC | 3.1.3.78 | ||||||||||
Accepted name: | phosphatidylinositol-4,5-bisphosphate 4-phosphatase | ||||||||||
Reaction: | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate | ||||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P 1-phosphatidyl-1D-myo-inositol 4-phosphate = PtdIns4P 1-phosphatidyl-1D-myo-inositol 5-phosphate = PtdIns5P 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate = PtdIns(3,4)P2 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate = PtdIns(3,5)P2 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = PtdIns(4,5)P2 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate = PtdIns(3,4,5)P3 |
||||||||||
Other name(s): | phosphatidylinositol-4,5-bisphosphate 4-phosphatase I; phosphatidylinositol-4,5-bisphosphate 4-phosphatase II; type I PtdIns-4,5-P2 4-Ptase; type II PtdIns-4,5-P2 4-Ptase; IpgD; PtdIns-4,5-P2 4-phosphatase type I; PtdIns-4,5-P2 4-phosphatase type II; type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase; type 1 4-phosphatase | ||||||||||
Systematic name: | 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase | ||||||||||
Comments: | Two pathways exist in mammalian cells to degrade 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2] [2]. One is catalysed by this enzyme and the other by EC 3.1.3.36, phosphoinositide 5-phosphatase, where the product is PtdIns4P. The enzyme from human is specific for PtdIns(4,5)P2 as substrate, as it cannot use PtdIns(3,4,5)P3, PtdIns(3,4)P2, PtdIns(3,5)P2, PtdIns5P, PtdIns4P or PtdIns3P [2]. In humans, the enzyme is localized to late endosomal/lysosomal membranes [2]. It can control nuclear levels of PtdIns5P and thereby control p53-dependent apoptosis [3]. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||
References: |
| ||||||||||
EC | 3.1.3.86 | ||||||||||
Accepted name: | phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase | ||||||||||
Reaction: | 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate | ||||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism, click here | |||||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate = PtdIns(3,4)P2 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate = PtdIns(3,4,5)P3 1-phosphatidyl-1D-myo-inositol 1,3,4,5-trisphosphate = PtdIns(1,3,4,5)P4 |
||||||||||
Other name(s): | SHIP1; SHIP2; SHIP; p150Ship | ||||||||||
Systematic name: | 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase | ||||||||||
Comments: | This enzyme hydrolyses 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. The enzyme also shows activity toward (PtdIns(1,3,4,5)P4) [5]. The enzyme is involved in several signal transduction pathways in the immune system leading to an adverse range of effects. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||
References: |
| ||||||||||