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Your query returned 3 entries. Printable version
EC | 1.14.14.73 | ||||||||||
Accepted name: | albendazole monooxygenase (sulfoxide-forming) | ||||||||||
Reaction: | (1) albendazole + [reduced NADPH—hemoprotein reductase] + O2 = albendazole S-oxide + [oxidized NADPH—hemoprotein reductase] + H2O (2) fenbendazole + [reduced NADPH—hemoprotein reductase] + O2 = fenbendazole S-oxide + [oxidized NADPH—hemoprotein reductase] + H2O |
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For diagram of albendazole metabolism, click here | |||||||||||
Glossary: | albendazole = methyl [5-(propylsulfanyl)-1H-benzimidazol-2-yl]carbamate fenbendazole = methyl [5-(phenylsulfanyl)-1H-benzimidazol-2-yl]carbamate |
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Other name(s): | albendazole sulfoxidase (ambiguous); albendazole hydroxylase (ambiguous); CYP3A4 (gene name); CYP2J2 (gene name); CYP1A2 (gene name) | ||||||||||
Systematic name: | albendazole,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (sulfoxide-forming) | ||||||||||
Comments: | This is one of the activities carried out by some microsomal cytochrome P-450 monooxygenases. A similar conversion is also carried out by a different microsomal enzyme (EC 1.14.13.32, albendazole monooxygenase (flavin-containing)), but it is estimated that cytochrome P-450s are responsible for 70% of the activity. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9059-22-7 | ||||||||||
References: |
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EC | 1.14.14.74 | ||||||||||
Accepted name: | albendazole monooxygenase (hydroxylating) | ||||||||||
Reaction: | albendazole + [reduced NADPH—hemoprotein reductase] + O2 = hydroxyalbendazole + [oxidized NADPH—hemoprotein reductase] + H2O | ||||||||||
For diagram of albendazole metabolism, click here | |||||||||||
Glossary: | albendazole = methyl [5-(propylsulfanyl)-1H-benzimidazol-2-yl]carbamate hydroxyalbendazole = methyl [5-(3-hydroxypropylsulfanyl)-1H-benzimidazol-2-yl]carbamate |
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Other name(s): | CYP2J2 (gene name) | ||||||||||
Systematic name: | albendazole,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (hydroxylating) | ||||||||||
Comments: | CYP2J2 is a microsomal cytochrome P-450 monooxygenase that catalyses the hydroxylation of the terminal carbon of the propylsulfanyl chain in albendazole, a broad-spectrum anthelmintic used against gastrointestinal nematodes and the larval stages of cestodes. cf. EC 1.14.14.73, albendazole monooxygenase (sulfoxide-forming). | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||
References: |
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EC | 1.14.14.75 | ||||||||||
Accepted name: | fenbendazole monooxygenase (4′-hydroxylating) | ||||||||||
Reaction: | fenbendazole + [reduced NADPH—hemoprotein reductase] + O2 = 4′-hydroxyfenbendazole + [oxidized NADPH—hemoprotein reductase] + H2O | ||||||||||
For diagram of albendazole metabolism, click here | |||||||||||
Glossary: | fenbendazole = methyl [5-(phenylsulfanyl)-1H-benzimidazol-2-yl]carbamate 4′-hydroxyfenbendazole = methyl [5-(4-hydroxyphenylsulfanyl)-1H-benzimidazol-2-yl]carbamate albendazole = methyl [5-(propylsulfanyl)-1H-benzimidazol-2-yl]carbamate |
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Other name(s): | CYP2C19 (gene name) | ||||||||||
Systematic name: | fenbendazole,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (4′-hydroxylating) | ||||||||||
Comments: | CYP2C19 is microsomal cytochrome P-450 monooxygenase that catalyses the hydroxylation of the benzene ring of fenbendazole, a broad-spectrum anthelmintic used against gastrointestinal nematodes and the larval stages of cestodes. This activity is also carried out by CYP2J2. cf. EC 1.14.14.74, albendazole monooxygenase (hydroxylating). CYP2C19 does not act on albendazole. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||
References: |
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