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Your query returned 5 entries. Printable version
EC | 1.21.98.1 | ||||||||||||||
Accepted name: | cyclic dehypoxanthinyl futalosine synthase | ||||||||||||||
Reaction: | dehypoxanthine futalosine + S-adenosyl-L-methionine = cyclic dehypoxanthinyl futalosine + 5′-deoxyadenosine + L-methionine | ||||||||||||||
For diagram of the futalosine pathway, click here | |||||||||||||||
Glossary: | dehypoxanthine futalosine = 3-{3-[(2R,3S,4R)-3,4,5-trihydroxytetrahydrofuran-2-yl]propanoyl}benzoate cyclic dehypoxanthinyl futalosine = (2R,3S,4R)-3,4,5-trihydroxy-4′-oxo-3′,4,4′,5-tetrahydro-2’H,3H-spiro[furan-2,1′-naphthalene]-6′-carboxylate |
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Other name(s): | MqnC; dehypoxanthinyl futalosine cyclase | ||||||||||||||
Systematic name: | dehypoxanthine futalosine:S-adenosyl-L-methionine oxidoreductase (cyclizing) | ||||||||||||||
Comments: | This enzyme is a member of the AdoMet radical (radical SAM) family. The enzyme, found in several bacterial species, is part of the futalosine pathway for menaquinone biosynthesis. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||||
References: |
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EC | 1.21.99.2 | ||||||||||||||
Transferred entry: | EC 1.21.99.2, cyclic dehypoxanthinyl futalosine synthase. Now classified as EC 1.21.98.1, cyclic dehypoxanthinyl futalosine synthase. | ||||||||||||||
EC | 3.2.2.26 | ||||||||||||||
Accepted name: | futalosine hydrolase | ||||||||||||||
Reaction: | futalosine + H2O = dehypoxanthine futalosine + hypoxanthine | ||||||||||||||
For diagram of the futalosine pathway, click here | |||||||||||||||
Glossary: | futalosine = 3-(3-((3S,4R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9(6H)-yl)tetrahydrofuran-2-yl)propanoyl)benzoate dehypoxanthine futalosine = 7-(3-carboxyphenyl)-D-ribo-7-dehydro-5,6-dideoxyheptose |
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Other name(s): | futalosine nucleosidase; MqnB (ambiguous) | ||||||||||||||
Systematic name: | futalosine ribohydrolase | ||||||||||||||
Comments: | This enzyme, which is specific for futalosine, catalyses the second step of a novel menaquinone biosynthetic pathway that is found in some prokaryotes. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||||
References: |
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EC | 3.2.2.30 | ||||||||||||||
Accepted name: | aminodeoxyfutalosine nucleosidase | ||||||||||||||
Reaction: | 6-amino-6-deoxyfutalosine + H2O = dehypoxanthine futalosine + adenine | ||||||||||||||
For diagram of the futalosine pathway, click here | |||||||||||||||
Glossary: | 6-amino-6-deoxyfutalosine = 3-{3-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]propanoyl}benzoate dehypoxanthine futalosine = 3-{3-[(2R,3S,4R)-3,4,5-trihydroxytetrahydrofuran-2-yl]propanoyl}benzoate |
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Other name(s): | AFL nucleosidase; aminofutalosine nucleosidase; methylthioadenosine nucleosidase; MqnB (ambiguous) | ||||||||||||||
Systematic name: | 6-amino-6-deoxyfutalosine ribohydrolase | ||||||||||||||
Comments: | The enzyme, found in several bacterial species, catalyses a step in a modified futalosine pathway for menaquinone biosynthesis. While the enzyme from some organisms also has the activity of EC 3.2.2.9, adenosylhomocysteine nucleosidase, the enzyme from Chlamydia trachomatis is specific for 6-amino-6-deoxyfutalosine [7]. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||||
References: |
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EC | 4.1.99.29 | ||||||||||||||
Accepted name: | 5,8-dihydroxy-2-naphthoate synthase | ||||||||||||||
Reaction: | cyclic dehypoxanthine futalosine = 5,8-dihydroxy-2-naphthoate + dihydroxyacetone | ||||||||||||||
For diagram of the futalosine pathway, click here | |||||||||||||||
Glossary: | cyclic dehypoxanthine futalosine = (1R,3′S,4′R)-3′,4′,5′-trihydroxy-4-oxo-2,3-dihydrospiro[naphthalene-1,2′-oxolane]-6-carboxylate 5,8-dihydroxy-2-naphthoate = 5,8-dihydroxynaphthalene-2-carboxylate |
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Other name(s): | mqnD (gene name); 1,4-dihydroxy-6-naphthoate synthase (incorrect) | ||||||||||||||
Systematic name: | cyclic dehypoxanthine futalosine lyase (dihydroxyacetone-forming) | ||||||||||||||
Comments: | The enzyme participates in alternative menaquinone biosynthesis pathways known as the futalosine and modified futalosine pathways, which occurs in some bacterial species including several human pathogens such as Helicobacter pylori, Campylobacter jejuni, and Chlamydia. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||||
References: |
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