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Your query returned 7 entries. Printable version
EC | 1.1.1.184 | ||||||
Accepted name: | carbonyl reductase (NADPH) | ||||||
Reaction: | R-CHOH-R′ + NADP+ = R-CO-R′ + NADPH + H+ | ||||||
Other name(s): | aldehyde reductase 1; prostaglandin 9-ketoreductase; xenobiotic ketone reductase; NADPH-dependent carbonyl reductase; ALR3; carbonyl reductase; nonspecific NADPH-dependent carbonyl reductase; carbonyl reductase (NADPH2) | ||||||
Systematic name: | secondary-alcohol:NADP+ oxidoreductase | ||||||
Comments: | Acts on a wide range of carbonyl compounds, including quinones, aromatic aldehydes, ketoaldehydes, daunorubicin and prostaglandins E and F, reducing them to the corresponding alcohol. Si-specific with respect to NADPH [cf. EC 1.1.1.2 alcohol dehydrogenase (NADP+)]. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 89700-36-7 | ||||||
References: |
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EC | 1.1.1.362 | ||||||
Accepted name: | aklaviketone reductase | ||||||
Reaction: | aklavinone + NADP+ = aklaviketone + NADPH + H+ | ||||||
For diagram of aflatoxin biosynthesis, click here | |||||||
Glossary: | aklavinone = methyl (1R,2R,4S)-2-ethyl-2,4,5,7-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate aklaviketone = methyl (1R,2R)-2-ethyl-2,5,7-trihydroxy-4,6,11-trioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate |
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Other name(s): | dauE (gene name); aknU (gene name) | ||||||
Systematic name: | aklavinone:NADP+ oxidoreductase | ||||||
Comments: | The enzyme is involved in the synthesis of the aklavinone aglycone, a common precursor for several anthracycline antibiotics including aclacinomycins, daunorubicin and doxorubicin. The enzyme from the Gram-negative bacterium Streptomyces sp. C5 produces daunomycin. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||
References: |
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EC | 1.14.13.180 | ||||||
Accepted name: | aklavinone 12-hydroxylase | ||||||
Reaction: | aklavinone + NADPH + H+ + O2 = ε-rhodomycinone + NADP+ + H2O | ||||||
For diagram of aflatoxin biosynthesis, click here | |||||||
Glossary: | aklavinone = methyl (1R,2R,4S)-2-ethyl-2,4,5,7-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate ε-rhodomycinone = methyl (1R,2R,4S)-2-ethyl-2,4,5,7,12-pentahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate |
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Other name(s): | DnrF; RdmE; aklavinone 11-hydroxylase (incorrect) | ||||||
Systematic name: | aklavinone,NADPH:oxygen oxidoreductase (12-hydroxylating) | ||||||
Comments: | The enzymes from the Gram-positive bacteria Streptomyces peucetius and Streptomyces purpurascens participate in the biosynthesis of daunorubicin, doxorubicin and rhodomycins. The enzyme from Streptomyces purpurascens is an FAD monooxygenase. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||
References: |
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EC | 1.14.13.181 | ||||||
Accepted name: | 13-deoxydaunorubicin hydroxylase | ||||||
Reaction: | (1) 13-deoxydaunorubicin + NADPH + H+ + O2 = 13-dihydrodaunorubicin + NADP+ + H2O (2) 13-dihydrodaunorubicin + NADPH + H+ + O2 = daunorubicin + NADP+ + 2 H2O |
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For diagram of daunorubicin biosynthesis, click here | |||||||
Glossary: | 13-dihydrodaunorubicin = daunorubicinol = (1S,3S)-3,5,12-trihydroxy-3-(1-hydroxyethyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside 13-deoxydaunorubicin = (1S,3S)-3-ethyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside daunorubicin = (1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside |
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Other name(s): | DoxA | ||||||
Systematic name: | 13-deoxydaunorubicin,NADPH:oxygen oxidoreductase (13-hydroxylating) | ||||||
Comments: | The enzymes from the Gram-positive bacteria Streptomyces sp. C5 and Streptomyces peucetius show broad substrate specificity for structures based on an anthracycline aglycone, but have a strong preference for 4-methoxy anthracycline intermediates (13-deoxydaunorubicin and 13-dihydrodaunorubicin) over their 4-hydroxy analogues (13-deoxycarminomycin and 13-dihydrocarminomycin), as well as a preference for substrates hydroxylated at the C-13 rather than the C-14 position. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||
References: |
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EC | 2.1.1.288 | ||||||
Accepted name: | aklanonic acid methyltransferase | ||||||
Reaction: | S-adenosyl-L-methionine + aklanonate = S-adenosyl-L-homocysteine + methyl aklanonate | ||||||
For diagram of aflatoxin biosynthesis, click here | |||||||
Glossary: | methyl aklanonate = methyl [1,4,5-trihydroxy-9,10-dioxo-3-(3-oxopentanoyl)-9,10-dihydroanthracen-2-yl]acetate aklanonate = [4,5-dihydroxy-9,10-dioxo-3-(3-oxopentanoyl)-9,10-dihydroanthracen-2-yl]acetic acid |
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Other name(s): | DauC; AAMT | ||||||
Systematic name: | S-adenosyl-L-methionine:aklanonate O-methyltransferase | ||||||
Comments: | The enzyme from the Gram-positive bacterium Streptomyces sp. C5 is involved in the biosynthesis of the anthracycline daunorubicin. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||
References: |
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EC | 2.1.1.292 | ||||||
Accepted name: | carminomycin 4-O-methyltransferase | ||||||
Reaction: | S-adenosyl-L-methionine + carminomycin = S-adenosyl-L-homocysteine + daunorubicin | ||||||
For diagram of daunorubicin biosynthesis, click here | |||||||
Glossary: | daunorubicin = (+)-daunomycin = (8S,10S)-8-acetyl-10-[(2S,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,8,11-trihydroxy-1-methoxy-9,10-dihydro-7H-tetracene-5,12-dione carminomycin = (1S,3S)-3-acetyl-3,5,10,12-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside = (1S,3S)-3-acetyl-3,5,10,12-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydronaphthacen-1-yl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside carubicin = (1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside = (8S,10S)-8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-6,8,11-trihydroxy-1-methoxy-7,8,9,10-tetrahydronaphthacene-5,12-dione |
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Other name(s): | DnrK; DauK | ||||||
Systematic name: | S-adenosyl-L-methionine:carminomycin 4-O-methyltransferase | ||||||
Comments: | The enzymes from the Gram-positive bacteria Streptomyces sp. C5 and Streptomyces peucetius are involved in the biosynthesis of the anthracycline daunorubicin. In vitro the enzyme from Streptomyces sp. C5 also catalyses the 4-O-methylation of 13-dihydrocarminomycin, rhodomycin D and 10-carboxy-13-deoxycarminomycin [3]. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||
References: |
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EC | 5.5.1.23 | ||||||
Accepted name: | aklanonic acid methyl ester cyclase | ||||||
Reaction: | aklaviketone = methyl aklanonate | ||||||
For diagram of aklavinone biosynthesis, click here | |||||||
Glossary: | aklaviketone = methyl (1R,2R)-2-ethyl-2,5,7-trihydroxy-4,6,11-trioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate methyl aklanonate = methyl [4,5-dihydroxy-9,10-dioxo-3-(3-oxopentanoyl)-9,10-dihydroanthracen-2-yl]acetate |
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Other name(s): | dauD (gene name); aknH (gene name); dnrD (gene name); methyl aklanonate cyclase; methyl aklanonate-aklaviketone isomerase (cyclizing); aklaviketone lyase (decyclizing) | ||||||
Systematic name: | aklaviketone lyase (ring-opening) | ||||||
Comments: | The enzyme is involved in the biosynthesis of aklaviketone, an intermediate in the biosynthetic pathways leading to formation of several anthracycline antibiotics, including aclacinomycin, daunorubicin and doxorubicin. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||
References: |
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