The Enzyme Database

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EC 2.4.1.318     
Accepted name: demethyllactenocin mycarosyltransferase
Reaction: dTDP-β-L-mycarose + demethyllactenocin = dTDP + demethylmacrocin
For diagram of tylosin biosynthesis, click here
Glossary: dTDP-β-L-mycarose = dTDP-2,6-dideoxy-3-C-methyl-β-L-ribo-hexose
demethyllactenocin = [(2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-{[3,6-dideoxy-3-(dimethylamino)-D-glucopyranosyl]oxy}-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-11-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-D-allopyranoside
Other name(s): tylCV (gene name); tylC5 (gene name)
Systematic name: dTDP-β-L-mycarose:demethyllactenocin 4′-O-α-L-mycarosyltransferase
Comments: The enzyme participates in the biosynthetic pathway of the macrolide antibiotic tylosin, which is produced by several species of Streptomyces bacteria.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Bate, N., Butler, A.R., Smith, I.P. and Cundliffe, E. The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin. Microbiology 146 (2000) 139–146. [DOI] [PMID: 10658660]
[EC 2.4.1.318 created 2014]
 
 
EC 2.4.1.328     
Accepted name: erythronolide mycarosyltransferase
Reaction: dTDP-β-L-mycarose + erythronolide B = dTDP + 3-α-L-mycarosylerythronolide B
For diagram of erythromycin biosynthesis, click here
Glossary: dTDP-β-L-mycarose = dTDP-2,6-dideoxy-3-C-methyl-β-L-ribo-hexose
L-mycarose = 2,6-dideoxy-3-C-methyl-L-ribo-hexose
Other name(s): EryBV
Systematic name: dTDP-β-L-mycarose:erythronolide B L-mycarosyltransferase
Comments: Isolated from the bacterium Saccharopolyspora erythraea. The enzyme is involved in the biosynthesis of the antibiotic erythromycin.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Zhang, C., Fu, Q., Albermann, C., Li, L. and Thorson, J.S. The in vitro characterization of the erythronolide mycarosyltransferase EryBV and its utility in macrolide diversification. ChemBioChem 8 (2007) 385–390. [DOI] [PMID: 17262863]
[EC 2.4.1.328 created 2014]
 
 


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