| EC |
2.6.1.106 |
| Accepted name: |
dTDP-3-amino-3,4,6-trideoxy-α-D-glucose transaminase |
| Reaction: |
dTDP-3-amino-3,4,6-trideoxy-α-D-glucose + 2-oxoglutarate = dTDP-3-dehydro-4,6-deoxy-α-D-glucose + L-glutamate |
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For diagram of dTDP-D-desosamine biosynthesis, click here |
| Glossary: |
dTDP-α-D-desosamine = dTDP-3-(dimethylamino)-3,4,6-trideoxy-α-D-glucose |
| Other name(s): |
desV (gene name); megDII (gene name); eryCI (gene name) |
| Systematic name: |
dTDP-3-amino-3,4,6-trideoxy-α-D-glucose:2-oxoglutarate aminotransferase |
| Comments: |
A pyridoxal-phosphate protein. The enzyme is involved in the biosynthesis of dTDP-α-D-desosamine, a sugar found in several bacterial macrolide antibiotics including erythromycin, megalomicin A, mycinamicin II, and oleandomycin. The reaction occurs in the reverse direction. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Burgie, E.S., Thoden, J.B. and Holden, H.M. Molecular architecture of DesV from Streptomyces venezuelae: a PLP-dependent transaminase involved in the biosynthesis of the unusual sugar desosamine. Protein Sci. 16 (2007) 887–896. [DOI] [PMID: 17456741] |
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| [EC 2.6.1.106 created 2014] |
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