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Your query returned 3 entries. Printable version
EC | 2.1.1.234 | ||||||
Accepted name: | dTDP-3-amino-3,4,6-trideoxy-α-D-glucopyranose N,N-dimethyltransferase | ||||||
Reaction: | 2 S-adenosyl-L-methionine + dTDP-3-amino-3,4,6-trideoxy-α-D-glucopyranose = 2 S-adenosyl-L-homocysteine + dTDP-3-dimethylamino-3,4,6-trideoxy-α-D-glucopyranose | ||||||
For diagram of dTDP-D-desosamine biosynthesis, click here | |||||||
Glossary: | α-D-desosamine = 3-dimethylamino-3,4,6-trideoxy-α-D-glucopyranose dTDP-3-dimethylamino-3,4,6-trideoxy-α-D-glucopyranose = dTDP-D-desosamine |
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Other name(s): | DesVI | ||||||
Systematic name: | S-adenosyl-L-methionine:dTDP-3-amino-3,4,6-trideoxy-α-D-glucopyranose 3-N,N-dimethyltransferase | ||||||
Comments: | The enzyme is involved in the biosynthesis of desosamine, a 3-(dimethylamino)-3,4,6-trideoxyhexose found in certain macrolide antibiotics such as erthyromycin, azithromycin, and clarithromycin. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||
References: |
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EC | 2.4.1.277 | ||||||
Accepted name: | 10-deoxymethynolide desosaminyltransferase | ||||||
Reaction: | dTDP-3-dimethylamino-3,4,6-trideoxy-α-D-glucopyranose + 10-deoxymethynolide = dTDP + 10-deoxymethymycin | ||||||
For diagram of methymycin biosynthesis, click here and for diagram of pikromycin biosynthesis, click here | |||||||
Glossary: | dTDP-3-dimethylamino-3,4,6-trideoxy-α-D-glucopyranose = dTDP-D-desosamine | ||||||
Other name(s): | glycosyltransferase DesVII; DesVII | ||||||
Systematic name: | dTDP-3-dimethylamino-3,4,6-trideoxy-α-D-glucopyranose:10-deoxymethynolide 3-dimethylamino-4,6-dideoxy-α-D-glucosyltransferase | ||||||
Comments: | DesVII is the glycosyltransferase responsible for the attachment of dTDP-D-desosamine to 10-deoxymethynolide or narbonolide during the biosynthesis of methymycin, neomethymycin, narbomycin, and pikromycin in the bacterium Streptomyces venezuelae. Activity requires an additional protein partner, DesVIII. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||
References: |
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EC | 2.4.1.278 | ||||||
Accepted name: | 3-α-mycarosylerythronolide B desosaminyl transferase | ||||||
Reaction: | dTDP-D-desosamine + 3-α-L-mycarosylerythronolide B = dTDP + erythromycin D | ||||||
For diagram of erythromycin biosynthesis, click here | |||||||
Glossary: | dTDP-D-desosamine = dTDP-3,4,6-trideoxy-3-(dimethylamino)-α-D-xylo-hexopyranose erythromycin D = (3R,4S,5S,6R,7R,9R,11R,12S,13R,14R)-4-(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyloxy)-14-ethyl-7,12-dihydroxy-6-[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyloxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione 3-O-α-mycarosylerythronolide B = (3R,4S,5R,6R,7R,9R,11R,12S,13R,14R)-4-(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyloxy)-14-ethyl-6,7,12-trihydroxy-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione |
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Other name(s): | EryCIII; dTDP-3-dimethylamino-4,6-dideoxy-α-D-glucopyranose:3-α-mycarosylerythronolide B 3-dimethylamino-4,6-dideoxy-α-D-glucosyltransferase | ||||||
Systematic name: | dTDP-3-dimethylamino-3,4,6-trideoxy-α-D-glucopyranose:3-α-mycarosylerythronolide B 3-dimethylamino-3,4,6-trideoxy-β-D-glucosyltransferase | ||||||
Comments: | The enzyme is involved in erythromycin biosynthesis. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||
References: |
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