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Your query returned 3 entries. Printable version
EC | 1.1.1.85 | ||||||||
Accepted name: | 3-isopropylmalate dehydrogenase | ||||||||
Reaction: | (2R,3S)-3-isopropylmalate + NAD+ = 4-methyl-2-oxopentanoate + CO2 + NADH + H+ (overall reaction) (1a) (2R,3S)-3-isopropylmalate + NAD+ = (2S)-2-isopropyl-3-oxosuccinate + NADH + H+ (1b) (2S)-2-isopropyl-3-oxosuccinate = 4-methyl-2-oxopentanoate + CO2 (spontaneous) |
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For diagram of leucine biosynthesis, click here | |||||||||
Other name(s): | β-isopropylmalic enzyme; β-isopropylmalate dehydrogenase; threo-Ds-3-isopropylmalate dehydrogenase; 3-carboxy-2-hydroxy-4-methylpentanoate:NAD+ oxidoreductase | ||||||||
Systematic name: | (2R,3S)-3-isopropylmalate:NAD+ oxidoreductase | ||||||||
Comments: | The product decarboxylates spontaneously to yield 4-methyl-2-oxopentanoate. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9030-97-1 | ||||||||
References: |
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EC | 2.3.3.13 | ||||||||
Accepted name: | 2-isopropylmalate synthase | ||||||||
Reaction: | acetyl-CoA + 3-methyl-2-oxobutanoate + H2O = (2S)-2-isopropylmalate + CoA | ||||||||
For diagram of leucine-biosynthesis pathway, click here | |||||||||
Other name(s): | 3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating); α-isopropylmalate synthetase; α-isopropylmalate synthase; α-isopropylmalic synthetase; isopropylmalate synthase; isopropylmalate synthetase | ||||||||
Systematic name: | acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming) | ||||||||
Comments: | Requires K+. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9030-98-2 | ||||||||
References: |
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EC | 4.2.1.33 | ||||||||
Accepted name: | 3-isopropylmalate dehydratase | ||||||||
Reaction: | (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate (overall reaction) (1a) (2R,3S)-3-isopropylmalate = 2-isopropylmaleate + H2O (1b) 2-isopropylmaleate + H2O = (2S)-2-isopropylmalate |
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For diagram of leucine biosynthesis, click here | |||||||||
Glossary: | α-isopropylmalate = (2S)-2-isopropylmalate β-isopropylmalate = (2R,3S)-3-isopropylmalate |
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Other name(s): | (2R,3S)-3-isopropylmalate hydro-lyase; β-isopropylmalate dehydratase; isopropylmalate isomerase; α-isopropylmalate isomerase; 3-isopropylmalate hydro-lyase | ||||||||
Systematic name: | (2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming) | ||||||||
Comments: | Forms part of the leucine biosynthesis pathway. The enzyme brings about the interconversion of the two isomers of isopropylmalate. It contains an iron-sulfur cluster. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37290-72-5 | ||||||||
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