|
Your query returned 2 entries. Printable version
EC | 2.4.2.48 | ||||
Accepted name: | tRNA-guanine15 transglycosylase | ||||
Reaction: | guanine15 in tRNA + 7-cyano-7-carbaguanine = 7-cyano-7-carbaguanine15 in tRNA + guanine | ||||
Glossary: | 7-cyano-7-carbaguanine = preQ0 = 7-cyano-7-deazaguanine archaeosine = G* = 7-amidino-7-deazaguanosine |
||||
Other name(s): | tRNA transglycosylase (ambiguous); transfer ribonucleate glycosyltransferase (ambiguous); tRNA guanine15 transglycosidase; TGT (ambiguous); transfer ribonucleic acid guanine15 transglycosylase | ||||
Systematic name: | tRNA-guanine15:7-cyano-7-carbaguanine tRNA-D-ribosyltransferase | ||||
Comments: | Archaeal tRNAs contain the modified nucleoside archaeosine at position 15. This archaeal enzyme catalyses the exchange of guanine at position 15 of tRNA with the base preQ0, which is ultimately modified to form the nucleoside archaeosine (cf. EC 2.6.1.97) [1]. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||
References: |
| ||||
EC | 2.6.1.97 | ||||
Accepted name: | archaeosine synthase | ||||
Reaction: | L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O = L-glutamate + archaeine15 in tRNA | ||||
Glossary: | 7-cyano-7-carbaguanine = preQ0 = 7-cyano-7-deazaguanine archaeine = 7-deaza-7-carbamidoylguanine = base G* archaeosine = G* = 7-amidino-7-deazaguanosine |
||||
Other name(s): | ArcS; TgtA2; MJ1022 (gene name); glutamine:preQ0-tRNA amidinotransferase (incorrect) | ||||
Systematic name: | L-glutamine:7-cyano-7-carbaguanine aminotransferase | ||||
Comments: | In Euryarchaeota the reaction is catalysed by ArcS [1,2]. In Crenarchaeota, which do not have an ArcS homologue, the reaction is catalysed either by a homologue of EC 6.3.4.20, 7-cyano-7-deazaguanine synthase that includes a glutaminase domain (cf. EC 3.5.1.2), or by a homologue of EC 1.7.1.13, preQ1 synthase [2]. The enzyme from the Euryarchaeon Methanocaldococcus jannaschii can also use arginine and ammonium as amino donors. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
References: |
| ||||