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Your query returned 5 entries. Printable version
EC | 2.5.1.16 | ||||||||||||||
Accepted name: | spermidine synthase | ||||||||||||||
Reaction: | S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5′-thioadenosine + spermidine | ||||||||||||||
For diagram of spermine biosynthesis, click here | |||||||||||||||
Glossary: | spermidine = N-(3-aminopropyl)butane-1,4-diamine spermine = N,N′-bis(3-aminopropyl)butane-1,4-diamine putrescine = butane-1,4-diamine S-adenosyl 3-(methylsulfanyl)propylamine = (3-aminopropyl){[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}methylsulfonium |
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Other name(s): | aminopropyltransferase; putrescine aminopropyltransferase; spermidine synthetase; SpeE (ambiguous); S-adenosylmethioninamine:putrescine 3-aminopropyltransferase; S-adenosyl 3-(methylthio)propylamine:putrescine 3-aminopropyltransferase | ||||||||||||||
Systematic name: | S-adenosyl 3-(methylsulfanyl)propylamine:putrescine 3-aminopropyltransferase | ||||||||||||||
Comments: | The enzymes from the plant Glycine max and from mammalia are highly specific for putrescine as the amine acceptor [2,7]. The enzymes from the bacteria Escherichia coli and Thermotoga maritima prefer putrescine but are more tolerant towards other amine acceptors, such as spermidine and cadaverine [5,6]. cf. EC 2.5.1.22 (spermine synthase) and EC 2.5.1.23 (sym-norspermidine synthase). | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37277-82-0 | ||||||||||||||
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EC | 2.5.1.22 | ||||||||||||||
Accepted name: | spermine synthase | ||||||||||||||
Reaction: | S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = S-methyl-5′-thioadenosine + spermine | ||||||||||||||
For diagram of spermine biosynthesis, click here | |||||||||||||||
Glossary: | spermidine = N-(3-aminopropyl)butane-1,4-diamine spermine = N,N′-bis(3-aminopropyl)butane-1,4-diamine S-adenosyl 3-(methylsulfanyl)propylamine = (3-aminopropyl){[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}methylsulfonium |
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Other name(s): | spermidine aminopropyltransferase; spermine synthetase; S-adenosylmethioninamine:spermidine 3-aminopropyltransferase; S-adenosyl 3-(methylthio)propylamine:spermidine 3-aminopropyltransferase | ||||||||||||||
Systematic name: | S-adenosyl 3-(methylsulfanyl)propylamine:spermidine 3-aminopropyltransferase | ||||||||||||||
Comments: | The enzyme from mammalia is highly specific for spermidine [2,3]. cf. EC 2.5.1.16 (spermidine synthase) and EC 2.5.1.23 (sym-norspermidine synthase). | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 74812-43-4 | ||||||||||||||
References: |
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EC | 2.5.1.23 | ||||||||||||||
Accepted name: | sym-norspermidine synthase | ||||||||||||||
Reaction: | S-adenosyl 3-(methylsulfanyl)propylamine + propane-1,3-diamine = S-methyl-5′-thioadenosine + bis(3-aminopropyl)amine | ||||||||||||||
Glossary: | S-adenosyl 3-(methylsulfanyl)propylamine = (3-aminopropyl){[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}methylsulfonium | ||||||||||||||
Other name(s): | S-adenosylmethioninamine:propane-1,3-diamine 3-aminopropyltransferase; S-adenosyl 3-(methylthio)propylamine:propane-1,3-diamine 3-aminopropyltransferase | ||||||||||||||
Systematic name: | S-adenosyl 3-(methylsulfanyl)propylamine:propane-1,3-diamine 3-aminopropyltransferase | ||||||||||||||
Comments: | The enzyme has been originally characterized from the protist Euglena gracilis [1,2]. The enzyme from the archaeon Sulfolobus solfataricus can transfer the propylamine moiety from S-adenosyl 3-(methylsulfanyl)propylamine to putrescine, sym-norspermidine and spermidine with lower efficiency [3]. cf. EC 2.5.1.16 (spermidine synthase) and EC 2.5.1.22 (spermine synthase). | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||||
References: |
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EC | 2.5.1.79 | ||||||||||||||
Accepted name: | thermospermine synthase | ||||||||||||||
Reaction: | S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = S-methyl-5′-thioadenosine + thermospermine + H+ | ||||||||||||||
Glossary: | thermospermine = N1-[3-(3-aminopropylamino)propyl]butane-1,4-diamine S-adenosyl 3-(methylsulfanyl)propylamine = (3-aminopropyl){[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}methylsulfonium |
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Other name(s): | TSPMS; ACL5; SAC51; S-adenosyl 3-(methylthio)propylamine:spermidine 3-aminopropyltransferase (thermospermine synthesizing) | ||||||||||||||
Systematic name: | S-adenosyl 3-(methylsulfanyl)propylamine:spermidine 3-aminopropyltransferase (thermospermine-forming) | ||||||||||||||
Comments: | This plant enzyme is crucial for the proper functioning of xylem vessel elements in the vascular tissues of plants [3]. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||||
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EC | 2.5.1.104 | ||||||||||||||
Accepted name: | N1-aminopropylagmatine synthase | ||||||||||||||
Reaction: | S-adenosyl 3-(methylsulfanyl)propylamine + agmatine = S-methyl-5′-thioadenosine + N1-(3-aminopropyl)agmatine | ||||||||||||||
For diagram of spermidine biosynthesis, click here | |||||||||||||||
Glossary: | S-adenosyl 3-(methylsulfanyl)propylamine = (3-aminopropyl){[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}methylsulfonium | ||||||||||||||
Other name(s): | agmatine/cadaverine aminopropyl transferase; ACAPT; PF0127 (gene name); triamine/agmatine aminopropyltransferase; SpeE (ambiguous); agmatine aminopropyltransferase; S-adenosyl 3-(methylthio)propylamine:agmatine 3-aminopropyltransferase | ||||||||||||||
Systematic name: | S-adenosyl 3-(methylsulfanyl)propylamine:agmatine 3-aminopropyltransferase | ||||||||||||||
Comments: | The enzyme is involved in the biosynthesis of spermidine from agmatine in some archaea and bacteria. The enzyme from the Gram-negative bacterium Thermus thermophilus accepts agmatine, spermidine and norspermidine with similar catalytic efficiency. The enzymes from the archaea Pyrococcus furiosus and Thermococcus kodakarensis prefer agmatine, but can utilize cadaverine, putrescine and propane-1,3-diamine with much lower catalytic efficiency. cf. EC 2.5.1.16, spermidine synthase, and EC 2.5.1.23, sym-norspermidine synthase. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||||
References: |
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