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Your query returned 4 entries. Printable version
EC | 1.14.13.247 | ||||
Accepted name: | stachydrine N-demethylase | ||||
Reaction: | L-proline betaine + NAD(P)H + H+ + O2 = N-methyl-L-proline + formaldehyde + NAD(P)+ + H2O | ||||
Other name(s): | L-proline betaine N-demethylase; stc2 (gene name) | ||||
Systematic name: | L-proline betaine,NAD(P)H:oxygen oxidoreductase (formaldehyde-forming) | ||||
Comments: | The enzyme, characterized from the bacterium Sinorhizobium meliloti 1021, consists of three different types of subunits. The catalytic unit contains a Rieske [2Fe-2S] iron-sulfur cluster, and catalyses the monooxygenation of a methyl group. The resulting N-methoxyl group is unstable and decomposes spontaneously to form formaldehyde. The other subunits are involved in the transfer of electrons from NAD(P)H to the catalytic subunit. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
References: |
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EC | 2.1.1.388 | ||||
Accepted name: | proline betaine—corrinoid protein Co-methyltransferase | ||||
Reaction: | L-proline betaine + a [Co(I) quaternary-amine-specific corrinoid protein] = a [methyl-Co(III) quaternary-amine-specific corrinoid protein] + N-methyl-L-proline | ||||
Glossary: | L-proline betaine = (2S)-1,1-dimethylpyrrolidinium-2-carboxylate | ||||
Other name(s): | mtpB (gene name) | ||||
Systematic name: | L-proline betaine:[Co(I) quaternary-amine-specific corrinoid protein] Co-methyltransferase | ||||
Comments: | The enzyme, characterized from the bacterium Eubacterium limosum, is a component of a system that transfers a methyl group from L-proline betaine to tetrahydrofolate, as part of an L-proline betaine degradation pathway. The resulting 5-methyltetrahydrofolate is processed to acetyl-CoA via the Wood—Ljungdahl pathway. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
References: |
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EC | 2.1.1.389 | ||||
Accepted name: | [methyl-Co(III) quaternary-amine-specific corrinoid protein]—tetrahydrofolate methyltransferase | ||||
Reaction: | a [methyl-Co(III) quaternary-amine-specific corrinoid protein] + tetrahydrofolate = N5-methyltetrahydrofolate + a [Co(I) quaternary-amine-specific corrinoid protein] | ||||
Other name(s): | mtqA (gene name) (ambiguous); [methyl-Co(III) MtqC corrinoid protein]—tetrahydrofolate methyltransferase | ||||
Systematic name: | [methyl-Co(III) quaternary-amine-specific corrinoid protein]:tetrahydrofolate methyltransferase | ||||
Comments: | The enzyme, characterized from the acetogenic gut bacterium Eubacterium limosum, participates in a pathway for the degradation of some quaternary amine compounds (L-proline betaine and L-carnitine). The enzyme catalyses the transfer of a methyl group bound to the cobalt cofactor of a dedicated corrinoid protein (bacterial MtqC) to tetrahydrofolate. The resulting 5-methyltetrahydrofolate is processed to acetyl-CoA via the Wood—Ljungdahl pathway. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
References: |
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EC | 5.1.1.22 | ||||
Accepted name: | 4-hydroxyproline betaine 2-epimerase | ||||
Reaction: | (1) trans-4-hydroxy-L-proline betaine = cis-4-hydroxy-D-proline betaine (2) L-proline betaine = D-proline betaine |
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Glossary: | trans-4-hydroxy-L-proline betaine = (2S,4R)-4-hydroxy-1,1-dimethylpyrrolidinium-2-carboxylate cis-4-hydroxy-D-proline betaine = (2R,4R)-4-hydroxy-1,1-dimethylpyrrolidinium-2-carboxylate L-proline betaine = (2S)-1,1-dimethylpyrrolidinium-2-carboxylate D-proline betaine = (2R)-1,1-dimethylpyrrolidinium-2-carboxylate |
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Other name(s): | hpbD (gene name); Hyp-B 2-epimerase; (4R)-4-hydroxyproline betaine 2-epimerase | ||||
Systematic name: | 4-hydroxyproline betaine 2-epimerase | ||||
Comments: | The enzyme, characterized from the bacteria Pelagibaca bermudensis and Paracoccus denitrificans, specifically catalyses racemization of trans-4-hydroxy-L-proline betaine and L-proline betaine at the C-2 position. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||
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