|
Your query returned 5 entries. Printable version
EC | 1.2.1.31 | ||||||||
Accepted name: | L-aminoadipate-semialdehyde dehydrogenase | ||||||||
Reaction: | (S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H + H+ (overall reaction) (1a) (S)-2-amino-6-oxohexanoate = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O (spontaneous) (1b) (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + NAD(P)+ + 2 H2O = L-2-aminoadipate + NAD(P)H + H+ |
||||||||
For diagram of lysine catabolism, click here and for diagram of L-Lysine synthesis, click here | |||||||||
Glossary: | (S)-2-amino-6-oxohexanoate = L-2-aminoadipate 6-semialdehyde = L-allysine L-1-piperideine 6-carboxylate = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate = (S)-1,6-didehydropiperidine-2-carboxylate |
||||||||
Other name(s): | aminoadipate semialdehyde dehydrogenase; 2-aminoadipate semialdehyde dehydrogenase; α-aminoadipate-semialdehyde dehydrogenase; α-aminoadipate reductase; 2-aminoadipic semialdehyde dehydrogenase; L-α-aminoadipate δ-semialdehyde oxidoreductase; L-α-aminoadipate δ-semialdehyde:NAD+ oxidoreductase; L-α-aminoadipate δ-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase; L-2-aminoadipate 6-semialdehyde:NAD(P)+ 6-oxidoreductase | ||||||||
Systematic name: | (S)-2-amino-6-oxohexanoate:NAD(P)+ 6-oxidoreductase | ||||||||
Comments: | (S)-2-amino-6-oxohexanoate undergoes a spontaneous dehydration forming the cyclic (S)-2,3,4,5-tetrahydropyridine-2-carboxylate, which serves as a substrate for the hydrogenation reaction. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9067-87-2 | ||||||||
References: |
| ||||||||
EC | 1.4.1.18 | ||||||||
Accepted name: | lysine 6-dehydrogenase | ||||||||
Reaction: | L-lysine + NAD+ = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + NADH + H+ + NH3 (overall reaction) (1a) L-lysine + NAD+ + H2O = (S)-2-amino-6-oxohexanoate + NADH + H+ + NH3 (1b) (S)-2-amino-6-oxohexanoate = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O (spontaneous) |
||||||||
For diagram of reaction, click here and for diagram of L-lysine synthesis, click here | |||||||||
Glossary: | (S)-2-amino-6-oxohexanoate = L-2-aminoadipate 6-semialdehyde = L-allysine L-1-piperideine 6-carboxylate = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate = (S)-1,6-didehydropiperidine-2-carboxylate |
||||||||
Other name(s): | L-lysine ε-dehydrogenase; L-lysine 6-dehydrogenase; LysDH | ||||||||
Systematic name: | L-lysine:NAD+ 6-oxidoreductase (deaminating) | ||||||||
Comments: | The enzyme is highly specific for L-lysine as substrate, although S-(2-aminoethyl)-L-cysteine can act as a substrate, but more slowly. While the enzyme from Agrobacterium tumefaciens can use only NAD+, that from the thermophilic bacterium Geobacillus stearothermophilus can also use NADP+, but more slowly [1,4]. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 89400-30-6 | ||||||||
References: |
| ||||||||
EC | 1.5.3.7 | ||||||||
Accepted name: | L-pipecolate oxidase | ||||||||
Reaction: | L-pipecolate + O2 = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2 | ||||||||
Glossary: | L-1-piperideine 6-carboxylate = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate = (S)-1,6-didehydropiperidine-2-carboxylate (S)-2-amino-6-oxohexanoate = L-2-aminoadipate 6-semialdehyde = L-allysine |
||||||||
Other name(s): | pipecolate oxidase; L-pipecolic acid oxidase | ||||||||
Systematic name: | L-pipecolate:oxygen 1,6-oxidoreductase | ||||||||
Comments: | The product reacts with water to form (S)-2-amino-6-oxohexanoate. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 81669-65-0 | ||||||||
References: |
| ||||||||
EC | 1.5.99.3 | ||||||||
Accepted name: | L-pipecolate dehydrogenase | ||||||||
Reaction: | L-pipecolate + acceptor = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + reduced acceptor | ||||||||
Glossary: | (S)-2-amino-6-oxohexanoate = L-2-aminoadipate 6-semialdehyde = L-allysine L-1-piperideine 6-carboxylate = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate = (S)-1,6-didehydropiperidine-2-carboxylate |
||||||||
Other name(s): | L-pipecolate:(acceptor) 1,6-oxidoreductase | ||||||||
Systematic name: | L-pipecolate:acceptor 1,6-oxidoreductase | ||||||||
Comments: | The product reacts with water to form (S)-2-amino-6-oxohexanoate. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9076-63-5 | ||||||||
References: |
| ||||||||
EC | 2.6.1.36 | ||||||||
Accepted name: | L-lysine 6-transaminase | ||||||||
Reaction: | L-lysine + 2-oxoglutarate = (S)-2-amino-6-oxohexanoate + L-glutamate | ||||||||
Glossary: | (S)-2-amino-6-oxohexanoate = L-2-aminoadipate 6-semialdehyde = L-allysine L-1-piperideine 6-carboxylate = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate = (S)-1,6-didehydropiperidine-2-carboxylate |
||||||||
Other name(s): | lysine 6-aminotransferase; lysine ε-aminotransferase; lysine ε-transaminase; lysine:2-ketoglutarate 6-aminotransferase; L-lysine-α-ketoglutarate aminotransferase; L-lysine-α-ketoglutarate 6-aminotransferase | ||||||||
Systematic name: | L-lysine:2-oxoglutarate 6-aminotransferase | ||||||||
Comments: | A pyridoxal-phosphate protein. The product (L-allysine) is converted into the intramolecularly dehydrated form, (S)-2,3,4,5-tetrahydropyridine-2-carboxylate. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9054-68-6 | ||||||||
References: |
| ||||||||