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Your query returned 3 entries. Printable version
EC | 1.14.13.182 | ||||
Accepted name: | 2-heptyl-3-hydroxy-4(1H)-quinolone synthase | ||||
Reaction: | 2-heptyl-4(1H)-quinolone + NADH + H+ + O2 = 2-heptyl-3-hydroxy-4(1H)-quinolone + NAD+ + H2O | ||||
Glossary: | 2-heptyl-4(1H)-quinolone = 2-heptyl-4-hydroxyquinoline 2-heptyl-3-hydroxy-4(1H)-quinolone = 2-heptyl-3,4-dihydroxyquinoline |
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Other name(s): | PqsH; 2-heptyl-3,4-dihydroxyquinoline synthase | ||||
Systematic name: | 2-heptyl-4(1H)-quinolone,NADH:oxygen oxidoreductase (3-hydroxylating) | ||||
Comments: | The enzyme from the bacterium Pseudomonas aeruginosa catalyses the terminal step in biosynthesis of the signal molecule 2-heptyl-3,4-dihydroxyquinoline that plays a role in regulation of virulence genes. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
References: |
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EC | 2.3.1.230 | ||||
Accepted name: | 2-heptyl-4(1H)-quinolone synthase | ||||
Reaction: | octanoyl-CoA + (2-aminobenzoyl)acetate = 2-heptyl-4-quinolone + CoA + CO2 + H2O (overall reaction) (1a) octanoyl-CoA + L-cysteinyl-[PqsC protein] = S-octanoyl-L-cysteinyl-[PqsC protein] + CoA (1b) S-octanoyl-L-cysteinyl-[PqsC protein] + (2-aminobenzoyl)acetate = 1-(2-aminophenyl)decane-1,3-dione + CO2 + L-cysteinyl-[PqsC protein] (1c) 1-(2-aminophenyl)decane-1,3-dione = 2-heptyl-4-quinolone + H2O |
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Glossary: | 2-heptyl-4-quinolone = 2-heptylquinolin-4(1H)-one | ||||
Other name(s): | pqsBC (gene names); malonyl-CoA:anthraniloyl-CoA C-acetyltransferase (decarboxylating) | ||||
Systematic name: | octanoyl-CoA:(2-aminobenzoyl)acetate octanoyltransferase | ||||
Comments: | The enzyme, characterized from the bacterium Pseudomonas aeruginosa, is a heterodimeric complex. The PqsC subunit acquires an octanoyl group from octanoyl-CoA and attaches it to an internal cysteine residue. Together with the PqsB subunit, the proteins catalyse the coupling of the octanoyl group with (2-aminobenzoyl)acetate, leading to decarboxylation and dehydration events that result in closure of the quinoline ring. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||
References: |
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EC | 3.1.2.32 | ||||
Accepted name: | 2-aminobenzoylacetyl-CoA thioesterase | ||||
Reaction: | (2-aminobenzoyl)acetyl-CoA + H2O = (2-aminobenzoyl)acetate + CoA | ||||
Other name(s): | pqsE (gene name) | ||||
Systematic name: | (2-aminobenzoyl)acetyl-CoA hydrolase | ||||
Comments: | The enzyme, characterized from the bacterium Pseudomonas aeruginosa, participates in the production of the signal molecule 2-heptyl-4(1H)-quinolone (HHQ). | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||
References: |
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