| EC |
1.1.1.401 |
| Accepted name: |
2-dehydro-3-deoxy-L-rhamnonate dehydrogenase (NAD+) |
| Reaction: |
2-dehydro-3-deoxy-L-rhamnonate + NAD+ = 2,4-didehydro-3-deoxy-L-rhamnonate + NADH + H+ |
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For diagram of L-rhamnose metabolism, click here |
| Other name(s): |
2-keto-3-deoxy-L-rhamnonate dehydrogenase |
| Systematic name: |
2-dehydro-3-deoxy-L-rhamnonate:NAD+ 4-oxidoreductase |
| Comments: |
The enzyme, characterized from the bacteria Sphingomonas sp. SKA58 and Sulfobacillus thermosulfidooxidans, is involved in the non-phosphorylative degradation pathway for L-rhamnose. It does not show any detectable activity with NADP+ or with other aldoses. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Watanabe, S. and Makino, K. Novel modified version of nonphosphorylated sugar metabolism - an alternative L-rhamnose pathway of Sphingomonas sp. FEBS J. 276 (2009) 1554–1567. [DOI] [PMID: 19187228] |
| 2. |
Bae, J., Kim, S.M. and Lee, S.B. Identification and characterization of 2-keto-3-deoxy-L-rhamnonate dehydrogenase belonging to the MDR superfamily from the thermoacidophilic bacterium Sulfobacillus thermosulfidooxidans: implications to L-rhamnose metabolism in archaea. Extremophiles 19 (2015) 469–478. [DOI] [PMID: 25617114] |
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| [EC 1.1.1.401 created 2016] |
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| EC |
4.1.2.53 |
| Accepted name: |
2-keto-3-deoxy-L-rhamnonate aldolase |
| Reaction: |
2-dehydro-3-deoxy-L-rhamnonate = pyruvate + (S)-lactaldehyde |
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For diagram of L-Rhamnose metabolism, click here |
| Glossary: |
2-dehydro-3-deoxy-L-rhamnonate = 3,6-dideoxy-L-erythro-hex-2-ulosonate |
| Other name(s): |
KDR aldolase; 2-dehydro-3-deoxyrhamnonate aldolase; 2-keto-3-deoxy acid sugar aldolase; YfaU; 2-dehydro-3-deoxy-L-rhamnonate (S)-lactaldehyde lyase (pyruvate-forming); 2-dehydro-3-deoxy-L-rhamnonate (R)-lactaldehyde lyase (pyruvate-forming) |
| Systematic name: |
2-dehydro-3-deoxy-L-rhamnonate (S)-lactaldehyde-lyase (pyruvate-forming) |
| Comments: |
Requires Mg2+ for activity. The enzyme can also use 2-oxo-3-deoxy-L-mannonate, 2-oxo-3-deoxy-L-lyxonate and 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) as substrates [2]. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Rakus, J.F., Fedorov, A.A., Fedorov, E.V., Glasner, M.E., Hubbard, B.K., Delli, J.D., Babbitt, P.C., Almo, S.C. and Gerlt, J.A. Evolution of enzymatic activities in the enolase superfamily: L-rhamnonate dehydratase. Biochemistry 47 (2008) 9944–9954. [DOI] [PMID: 18754693] |
| 2. |
Rea, D., Hovington, R., Rakus, J.F., Gerlt, J.A., Fulop, V., Bugg, T.D. and Roper, D.I. Crystal structure and functional assignment of YfaU, a metal ion dependent class II aldolase from Escherichia coli K12. Biochemistry 47 (2008) 9955–9965. [DOI] [PMID: 18754683] |
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| [EC 4.1.2.53 created 2013] |
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| EC |
4.2.1.90 |
| Accepted name: |
L-rhamnonate dehydratase |
| Reaction: |
L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O |
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For diagram of L-rhamnose metabolism, click here |
| Other name(s): |
L-rhamnonate hydro-lyase |
| Systematic name: |
L-rhamnonate hydro-lyase (2-dehydro-3-deoxy-L-rhamnonate-forming) |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 99533-47-8 |
| References: |
| 1. |
Rigo, L.U., Maréchal, L.R., Vieira, M.M. and Veiga, L.A. Oxidative pathway for L-rhamnose degradation in Pallularia pullulans. Can. J. Microbiol. 31 (1985) 817–822. |
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| [EC 4.2.1.90 created 1989] |
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