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Your query returned 28 entries. Printable version
EC | 2.3.1.265 | ||||||||||||
Accepted name: | phosphatidylinositol dimannoside acyltransferase | ||||||||||||
Reaction: | (1) an acyl-CoA + 2,6-di-O-α-D-mannosyl-1-phosphatidyl-1D-myo-inositol = CoA + 2-O-(6-O-acyl-α-D-mannosyl)-6-O-α-D-mannosyl-1-phosphatidyl-1D-myo-inositol (2) an acyl-CoA + 2-O-α-D-mannosyl-1-phosphatidyl-1D-myo-inositol = CoA + 2-O-(6-O-acyl-α-D-mannosyl)-1-phosphatidyl-1D-myo-inositol |
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Other name(s): | PIM2 acyltransferase; ptfP1 (gene name) | ||||||||||||
Systematic name: | acyl-CoA:2,6-di-O-α-D-mannosyl-1-phosphatidyl-1D-myo-inositol acyltransferase | ||||||||||||
Comments: | The enzyme, found in Corynebacteriales, is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIMs). | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||
References: |
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EC | 2.4.1.57 | ||||||||||||
Deleted entry: | phosphatidylinositol α-mannosyltransferase. Newer studies have shown that this is catalysed by two independent activities now covered by EC 2.4.1.345, phosphatidyl-myo-inositol α-mannosyl transferase and EC 2.4.1.346, phosphatidyl-myo-inositol dimannoside synthase | ||||||||||||
EC | 2.4.1.198 | ||||||||||||
Accepted name: | phosphatidylinositol N-acetylglucosaminyltransferase | ||||||||||||
Reaction: | UDP-N-acetyl-α-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6-(N-acetyl-α-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol | ||||||||||||
For diagram of glycosylphosphatidyl-myo-inositol biosynthesis, click here | |||||||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol = PtdIns | ||||||||||||
Other name(s): | UDP-N-acetyl-D-glucosamine:phosphatidylinositol N-acetyl-D-glucosaminyltransferase; uridine diphosphoacetylglucosamine α1,6-acetyl-D-glucosaminyltransferase; UDP-N-acetyl-D-glucosamine:1-phosphatidyl-1D-myo-inositol 6-(N-acetyl-α-D-glucosaminyl)transferase | ||||||||||||
Systematic name: | UDP-N-acetyl-α-D-glucosamine:1-phosphatidyl-1D-myo-inositol 6-(N-acetyl-α-D-glucosaminyl)transferase (configuration-retaining) | ||||||||||||
Comments: | Involved in the first step of glycosylphosphatidylinositol (GPI) anchor formation in all eukaryotes. In mammalian cells, the enzyme is composed of at least five subunits (PIG-A, PIG-H, PIG-C, GPI1 and PIG-P). PIG-A subunit is the catalytic subunit. In some species, the long-chain acyl groups of the phosphatidyl group are partly replaced by long-chain alkyl or alk-1-enyl groups. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 144388-35-2 | ||||||||||||
References: |
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EC | 2.4.1.345 | ||||||||||||
Accepted name: | phosphatidyl-myo-inositol α-mannosyltransferase | ||||||||||||
Reaction: | GDP-α-D-mannose + 1-phosphatidyl-1D-myo-inositol = GDP + 2-O-(α-D-mannosyl)-1-phosphatidyl-1D-myo-inositol | ||||||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol = PtdIns | ||||||||||||
Other name(s): | mannosyltransferase PimA; PimA; guanosine diphosphomannose-phosphatidyl-inositol α-mannosyltransferase (ambiguous) | ||||||||||||
Systematic name: | GDP-α-D-mannose:1-phosphatidyl-1D-myo-inositol 2-α-D-mannosyltransferase (configuration-retaining) | ||||||||||||
Comments: | Requires Mg2+. The enzyme, found in Corynebacteriales, is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIMs). | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||
References: |
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EC | 2.4.1.346 | ||||||||||||
Accepted name: | phosphatidyl-myo-inositol dimannoside synthase | ||||||||||||
Reaction: | (1) GDP-α-D-mannose + 2-O-α-D-mannosyl-1-phosphatidyl-1D-myo-inositol = GDP + 2,6-di-O-α-D-mannosyl-1-phosphatidyl-1D-myo-inositol (2) GDP-α-D-mannose + 2-O-(6-O-acyl-α-D-mannosyl)-1-phosphatidyl-1D-myo-inositol = GDP + 2-O-(6-O-acyl-α-D-mannosyl)-6-O-α-D-mannosyl-1-phosphatidyl-1D-myo-inositol |
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Glossary: | 1-phosphatidyl-1D-myo-inositol = PtdIns | ||||||||||||
Other name(s): | mannosyltransferase PimB; PimB; guanosine diphosphomannose-phosphatidyl-inositol α-mannosyltransferase (ambiguous) | ||||||||||||
Systematic name: | GDP-α-D-mannose:2-O-α-D-mannosyl-1-phosphatidyl-1D-myo-inositol 6-α-D-mannosyltransferase (configuration-retaining) | ||||||||||||
Comments: | Requires Mg2+. The enzyme, found in Corynebacteriales, is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIMs). | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||
References: |
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EC | 2.7.1.67 | ||||||||||||
Accepted name: | 1-phosphatidylinositol 4-kinase | ||||||||||||
Reaction: | ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | ||||||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism, click here | |||||||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol = PtdIns 1-phosphatidyl-1D-myo-inositol 4-phosphate = PtdIns4P |
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Other name(s): | phosphatidylinositol kinase (phosphorylating); phosphatidylinositol 4-kinase; phosphatidylinositol kinase; type II phosphatidylinositol kinase; PI kinase; PI 4-kinase | ||||||||||||
Systematic name: | ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase | ||||||||||||
Comments: | This reaction is catalysed by at least two different isoforms. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 37205-54-2 | ||||||||||||
References: |
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EC | 2.7.1.68 | ||||||||||||
Accepted name: | 1-phosphatidylinositol-4-phosphate 5-kinase | ||||||||||||
Reaction: | ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | ||||||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism (part 2), click here | |||||||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol = PtdIns 1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P 1-phosphatidyl-1D-myo-inositol 4-phosphate = PtdIns4P 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate = PtdIns(3,4)P2 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = PtdIns(4,5)P2 |
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Other name(s): | diphosphoinositide kinase; PIP kinase; phosphatidylinositol 4-phosphate kinase; phosphatidylinositol-4-phosphate 5-kinase; type I PIP kinase | ||||||||||||
Systematic name: | ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase | ||||||||||||
Comments: | This enzyme can also phosphorylate PtdIns3P in the 4-position, and PtdIns, PtdIns3P and PtdIns(3,4)P2 in the 5-position in vitro, but to a lesser extent. The last of these reactions occurs in vivo and is physiologically relevant. Three different isoforms are known. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 104645-76-3 | ||||||||||||
References: |
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EC | 2.7.1.137 | ||||||||||||
Accepted name: | phosphatidylinositol 3-kinase | ||||||||||||
Reaction: | ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | ||||||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism, click here | |||||||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol = PtdIns 1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P |
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Other name(s): | 1-phosphatidylinositol 3-kinase; type III phosphoinositide 3-kinase; Vps34p; type I phosphatidylinositol kinase | ||||||||||||
Systematic name: | ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase | ||||||||||||
Comments: | One mammalian isoform is known. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 115926-52-8 | ||||||||||||
References: |
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EC | 2.7.1.149 | ||||||||||||
Accepted name: | 1-phosphatidylinositol-5-phosphate 4-kinase | ||||||||||||
Reaction: | ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | ||||||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism (part 2), click here | |||||||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol 5-phosphate = PtdIns5P 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = PtdIns(4,5)P2 |
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Other name(s): | type II PIP kinase | ||||||||||||
Systematic name: | ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 247907-17-1 | ||||||||||||
References: |
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EC | 2.7.1.150 | ||||||||||||
Accepted name: | 1-phosphatidylinositol-3-phosphate 5-kinase | ||||||||||||
Reaction: | ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate | ||||||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism, click here | |||||||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate = PtdIns(3,5)P2 |
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Other name(s): | type III PIP kinase; phosphatidylinositol 3-phosphate 5-kinase | ||||||||||||
Systematic name: | ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||
References: |
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EC | 2.7.1.153 | ||||||||||||
Accepted name: | phosphatidylinositol-4,5-bisphosphate 3-kinase | ||||||||||||
Reaction: | ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate | ||||||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism (part 2), click here | |||||||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol = PtdIns 1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P 1-phosphatidyl-1D-myo-inositol 4-phosphate = PtdIns4P 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate = PtdIns(3,4)P2 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = PtdIns(4,5)P2 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate = PtdIns(3,4,5)P3 |
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Other name(s): | type I phosphoinositide 3-kinase | ||||||||||||
Systematic name: | ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase | ||||||||||||
Comments: | This enzyme also catalyses the phosphorylation of PtdIns4P to PtdIns(3,4)P2, and of PtdIns to PtdIns3P. Four mammalian isoforms are known to exist. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 103843-30-7 | ||||||||||||
References: |
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EC | 2.7.1.154 | ||||||||||||
Accepted name: | phosphatidylinositol-4-phosphate 3-kinase | ||||||||||||
Reaction: | ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate | ||||||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism, click here | |||||||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol = PtdIns 1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P 1-phosphatidyl-1D-myo-inositol 4-phosphate = PtdIns4P 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate = PtdIns(3,4)P2 |
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Other name(s): | type II phosphoinositide 3-kinase; C2-domain-containing phosphoinositide 3-kinase; phosphoinositide 3-kinase | ||||||||||||
Systematic name: | ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase | ||||||||||||
Comments: | This enzyme also phosphorylates PtdIns to PtdIns3P. Three mammalian isoforms have been found to date. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 141176-94-5 | ||||||||||||
References: |
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EC | 2.7.1.227 | ||||||||||||
Accepted name: | inositol phosphorylceramide synthase | ||||||||||||
Reaction: | 1-phosphatidyl-1D-myo-inositol + a very-long-chain (2′R)-2′-hydroxy-phytoceramide = 1,2-diacyl-sn-glycerol + a (4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-[(1D-myo-inositol-1-O-yl)hydroxyphosphoryl]sphinganine | ||||||||||||
Glossary: | a (4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-[(1D-myo-inositol-1-O-yl)hydroxyphosphoryl]sphinganine = a very-long-chain inositol phospho-α hydroxyphytoceramide = IPC | ||||||||||||
Other name(s): | AUR1 (gene name); KEI1 (gene name) | ||||||||||||
Systematic name: | 1-phosphatidyl-1D-myo-inositol:a very-long-chain (2′R)-2′-hydroxy-phytoceramide phosphoinositoltransferase | ||||||||||||
Comments: | The enzyme, characterized from yeast, attaches a phosphoinositol headgroup to α-hydroxyphytoceramides, generating a very-long-chain inositol phospho-α hydroxyphytoceramide (IPC), the simplest of the three complex sphingolipids produced by yeast. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||
References: |
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EC | 2.7.1.228 | ||||||||||||
Accepted name: | mannosyl-inositol-phosphoceramide inositolphosphotransferase | ||||||||||||
Reaction: | 1-phosphatidyl-1D-myo-inositol + a (4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-{[6-O-(α-D-mannosyl)-1D-myo-inositol-1-O-yl]hydroxyphosphoryl}sphinganine = 1,2-diacyl-sn-glycerol + a (4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-[(6-O-{6-O-[(1D-myo-inositol-1-O-yl)hydroxyphosphoryl]-α-D-mannosyl}-1D-myo-inositol-1-O-yl)hydroxyphosphoryl]sphinganine | ||||||||||||
Glossary: | a (4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-{[6-O-(α-D-mannosyl)-1D-myo-inositol-1-O-yl]hydroxyphosphoryl}sphinganine = a very-long-chain mannosylinositol phospho-α-hydroxyphytoceramide = MIPC a (4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-[(6-O-{6-O-[(1D-myo-inositol-1-O-yl)hydroxyphosphoryl]-α-D-mannosyl}-1D-myo-inositol-1-O-yl)hydroxyphosphoryl]sphinganine = a very-long-chain mannosyl-diphosphoinositol-α-hydroxyphytoceramide = MIP2C |
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Other name(s): | IPT1 (gene name) | ||||||||||||
Systematic name: | 1-phosphatidyl-1D-myo-inositol:(4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-{[6-O-(α-D-mannosyl)-1D-myo-inositol-1-O-yl]hydroxyphosphoryl}sphinganine phosphoinositoltransferase | ||||||||||||
Comments: | This enzyme catalyses the ultimate reaction in the yeast sphingolipid biosynthesis pathway. It transfers a second phosphoinositol group to mannosyl-inositol-phospho-α-hydroxyphytoceramide (MIPC), forming the final and most abundant yeast sphingolipid, mannosyl-diphosphoinositol-ceramide (MIP2C). | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||
References: |
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EC | 2.7.8.11 | ||||||||||||
Accepted name: | CDP-diacylglycerol—inositol 3-phosphatidyltransferase | ||||||||||||
Reaction: | CDP-diacylglycerol + myo-inositol = CMP + 1-phosphatidyl-1D-myo-inositol | ||||||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism, click here | |||||||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol = PtdIns | ||||||||||||
Other name(s): | CDP-diglyceride-inositol phosphatidyltransferase; phosphatidylinositol synthase; CDP-diacylglycerol-inositol phosphatidyltransferase; CDP-diglyceride:inositol transferase; cytidine 5′-diphospho-1,2-diacyl-sn-glycerol:myo-inositol 3-phosphatidyltransferase; CDP-DG:inositol transferase; cytidine diphosphodiglyceride-inositol phosphatidyltransferase; CDP-diacylglycerol:myo-inositol-3-phosphatidyltransferase; CDP-diglyceride-inositol transferase; cytidine diphosphoglyceride-inositol phosphatidyltransferase; cytidine diphosphoglyceride-inositol transferase | ||||||||||||
Systematic name: | CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9027-01-4 | ||||||||||||
References: |
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EC | 3.1.1.118 | ||||||||||||
Accepted name: | phospholipid sn-1 acylhydrolase | ||||||||||||
Reaction: | (1) a 1-phosphatidyl-1D-myo-inositol + H2O = a 2-acyl-sn-glycero-3-phospho-1D-myo-inositol + a fatty acid (2) a 1,2-diacyl-sn-glycerol 3-phosphate + H2O = a 2-acyl-sn-glycerol 3-phosphate + a fatty acid |
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Glossary: | a 1,2-diacyl-sn-glycerol 3-phosphate = a phosphatidate | ||||||||||||
Other name(s): | phospholipase DDHD1; phosphatidic acid-preferring phospholipase A1; PA-PLA1; DDHD1 (gene name) | ||||||||||||
Systematic name: | phospholipid sn-1 acylhydrolase | ||||||||||||
Comments: | The human enzyme shows broad specificity, and has a preference for phosphatidate over other phospholipids. Unlike EC 3.1.1.32, phospholipase A1, it is also active against phosphatidylinositol. It is not active towards acyl groups linked at the sn-2 position. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||
References: |
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EC | 3.1.3.36 | ||||||||||||
Accepted name: | phosphoinositide 5-phosphatase | ||||||||||||
Reaction: | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate | ||||||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism, click here | |||||||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol 4-phosphate = PtdIns4P 1-phosphatidyl-1D-myo-inositol 1,4-bisphosphate = PtdIns(1,4)P2 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = PtdIns(4,5)P2 1-phosphatidyl-1D-myo-inositol 1,3,4-trisphosphate = PtdIns(1,3,4)P3 1-phosphatidyl-1D-myo-inositol 1,4,5-trisphosphate = PtdIns(1,4,5)P3 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate = PtdIns(3,4,5)P3 1-phosphatidyl-1D-myo-inositol 1,3,4,5-tetrakisphosphate = PtdIns(1,3,4,5)P4 |
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Other name(s): | type II inositol polyphosphate 5-phosphatase; triphosphoinositide phosphatase; IP3 phosphatase; PtdIns(4,5)P2 phosphatase; triphosphoinositide phosphomonoesterase; diphosphoinositide phosphatase; inositol 1,4,5-triphosphate 5-phosphomonoesterase; inositol triphosphate 5-phosphomonoesterase; phosphatidylinositol-bisphosphatase; phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase; phosphatidylinositol 4,5-bisphosphate phosphatase; polyphosphoinositol lipid 5-phosphatase; phosphatidyl-inositol-bisphosphate phosphatase | ||||||||||||
Systematic name: | phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase | ||||||||||||
Comments: | These enzymes can also remove the 5-phosphate from Ins(1,4,5)P3 and/or Ins(1,3,4,5)P4. They are a diverse family of enzymes, with differing abilities to catalyse two or more of the four reactions listed. They are thought to use inositol lipids rather than inositol phosphates as substrates in vivo. All of them can use either or both of PtdIns(4,5)P2 and PtdIns(3,4,5)P3 as substrates; this is the main property that distinguishes them from EC 3.1.3.56, inositol-polyphosphate 5-phosphatase. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9036-01-5 | ||||||||||||
References: |
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EC | 3.1.3.64 | ||||||||||||
Accepted name: | phosphatidylinositol-3-phosphatase | ||||||||||||
Reaction: | 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate | ||||||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism, click here | |||||||||||||
Glossary: | inositol 1-phosphate = Ins-1-P inositol 1,3-bisphosphate = Ins(1,3)P2 1-phosphatidyl-1D-myo-inositol = PtdIns 1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P |
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Other name(s): | inositol-1,3-bisphosphate 3-phosphatase; inositol 1,3-bisphosphate phosphatase; inositol-polyphosphate 3-phosphatase; D-myo-inositol-1,3-bisphosphate 3-phosphohydrolase; phosphatidyl-3-phosphate 3-phosphohydrolase | ||||||||||||
Systematic name: | 1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase | ||||||||||||
Comments: | This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3)P2 to Ins-1-P. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 124248-47-1 | ||||||||||||
References: |
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EC | 3.1.3.66 | ||||||||||||
Accepted name: | phosphatidylinositol-3,4-bisphosphate 4-phosphatase | ||||||||||||
Reaction: | 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate | ||||||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism, click here | |||||||||||||
Glossary: | inositol 3-phosphate = Ins-3-P inositol 1,3-bisphosphate = Ins(1,3)P2 inositol 3,4-bisphosphate = Ins(3,4)P2 inositol 1,3,4-trisphosphate = Ins(1,3,4)P3 1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P 1-phosphatidyl-1D-myo-inositol 4-phosphate = PtdIns4P |
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Other name(s): | inositol-3,4-bisphosphate 4-phosphatase; D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase; phosphoinositide 4-phosphatase; inositol polyphosphate 4-phosphatase; inositol polyphosphate 4-phosphatase type II | ||||||||||||
Systematic name: | 1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase | ||||||||||||
Comments: | Mg2+-independent. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3,4)P3 to Ins(1,3)P2. It also converts Ins(3,4)P2 into Ins-3-P. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 123644-80-4 | ||||||||||||
References: |
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EC | 3.1.3.67 | ||||||||||||
Accepted name: | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase | ||||||||||||
Reaction: | 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + phosphate | ||||||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism, click here | |||||||||||||
Glossary: | inositol 1,4,5-trisphosphate = Ins(1,4,5)P3 inositol 1,3,4,5-tetrakisphosphate = Ins(1,3,4,5)P4 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = PtdIns(4,5)P2 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate = PtdIns(3,4,5)P3 |
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Other name(s): | PTEN (gene name); MMAC1 (gene name); phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase | ||||||||||||
Systematic name: | 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase | ||||||||||||
Comments: | Requires Mg2+. Does not dephosphorylate inositol 4,5-bisphosphate. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3,4,5)P4 to Ins(1,4,5)P3 | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 210488-47-4 | ||||||||||||
References: |
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EC | 3.1.3.78 | ||||||||||||
Accepted name: | phosphatidylinositol-4,5-bisphosphate 4-phosphatase | ||||||||||||
Reaction: | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate | ||||||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P 1-phosphatidyl-1D-myo-inositol 4-phosphate = PtdIns4P 1-phosphatidyl-1D-myo-inositol 5-phosphate = PtdIns5P 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate = PtdIns(3,4)P2 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate = PtdIns(3,5)P2 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = PtdIns(4,5)P2 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate = PtdIns(3,4,5)P3 |
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Other name(s): | phosphatidylinositol-4,5-bisphosphate 4-phosphatase I; phosphatidylinositol-4,5-bisphosphate 4-phosphatase II; type I PtdIns-4,5-P2 4-Ptase; type II PtdIns-4,5-P2 4-Ptase; IpgD; PtdIns-4,5-P2 4-phosphatase type I; PtdIns-4,5-P2 4-phosphatase type II; type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase; type 1 4-phosphatase | ||||||||||||
Systematic name: | 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase | ||||||||||||
Comments: | Two pathways exist in mammalian cells to degrade 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2] [2]. One is catalysed by this enzyme and the other by EC 3.1.3.36, phosphoinositide 5-phosphatase, where the product is PtdIns4P. The enzyme from human is specific for PtdIns(4,5)P2 as substrate, as it cannot use PtdIns(3,4,5)P3, PtdIns(3,4)P2, PtdIns(3,5)P2, PtdIns5P, PtdIns4P or PtdIns3P [2]. In humans, the enzyme is localized to late endosomal/lysosomal membranes [2]. It can control nuclear levels of PtdIns5P and thereby control p53-dependent apoptosis [3]. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||
References: |
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EC | 3.1.3.86 | ||||||||||||
Accepted name: | phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase | ||||||||||||
Reaction: | 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate | ||||||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism, click here | |||||||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate = PtdIns(3,4)P2 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate = PtdIns(3,4,5)P3 1-phosphatidyl-1D-myo-inositol 1,3,4,5-trisphosphate = PtdIns(1,3,4,5)P4 |
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Other name(s): | SHIP1; SHIP2; SHIP; p150Ship | ||||||||||||
Systematic name: | 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase | ||||||||||||
Comments: | This enzyme hydrolyses 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. The enzyme also shows activity toward (PtdIns(1,3,4,5)P4) [5]. The enzyme is involved in several signal transduction pathways in the immune system leading to an adverse range of effects. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||
References: |
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EC | 3.1.3.95 | ||||||||||||
Accepted name: | phosphatidylinositol-3,5-bisphosphate 3-phosphatase | ||||||||||||
Reaction: | 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate | ||||||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol 5-phosphate = PtdIns5P 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate = PtdIns(3,5)P2 |
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Other name(s): | MTMR; PtdIns-3,5-P2 3-Ptase | ||||||||||||
Systematic name: | 1-phosphatidyl-1D-myo-inositol-3,5-bisphosphate 3-phosphohydrolase | ||||||||||||
Comments: | The enzyme is found in both plants and animals. It also has the activity of EC 3.1.3.64 (phosphatidylinositol-3-phosphatase). | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||
References: |
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EC | 3.1.4.11 | ||||||||||||
Accepted name: | phosphoinositide phospholipase C | ||||||||||||
Reaction: | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol | ||||||||||||
For diagram of myo-inositol-phosphate biosynthesis, click here | |||||||||||||
Other name(s): | triphosphoinositide phosphodiesterase; phosphoinositidase C; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase; monophosphatidylinositol phosphodiesterase; phosphatidylinositol phospholipase C; PI-PLC; 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase | ||||||||||||
Systematic name: | 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase | ||||||||||||
Comments: | These enzymes form some of the cyclic phosphate Ins(cyclic1,2)P(4,5)P2 as well as Ins(1,4,5)P3. They show activity towards phosphatidylinositol, i.e., the activity of EC 4.6.1.13, phosphatidylinositol diacylglycerol-lyase, in vitro at high [Ca2+]. Four β-isoforms regulated by G-proteins, two γ-forms regulated by tyrosine kinases, four δ-forms regulated at least in part by calcium and an ε-form, probably regulated by the oncogene ras, have been found. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 63551-76-8 | ||||||||||||
References: |
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EC | 3.1.4.50 | ||||||||||||
Accepted name: | glycosylphosphatidylinositol phospholipase D | ||||||||||||
Reaction: | 6-(α-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = 6-(α-D-glucosaminyl)-1D-myo-inositol + 3-sn-phosphatidate | ||||||||||||
For diagram of glycosylphosphatidyl-myo-inositol biosynthesis, click here | |||||||||||||
Other name(s): | GPI-PLD; glycoprotein phospholipase D; phosphatidylinositol phospholipase D; phosphatidylinositol-specific phospholipase D | ||||||||||||
Systematic name: | glycoprotein-phosphatidylinositol phosphatidohydrolase | ||||||||||||
Comments: | This enzyme is also active when O-4 of the glucosamine is substituted by carrying the oligosaccharide that can link a protein to the structure. It therefore cleaves proteins from the lipid part of the glycosylphosphatidylinositol (GPI) anchors, but does so by hydrolysis, whereas glycosylphosphatidylinositol diacylglycerol-lyase (EC 4.6.1.14) does so by elimination. It acts on plasma membranes only after solubilization of the substrate with detergents or solvents, but it may act on intracellular membranes. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 113756-14-2 | ||||||||||||
References: |
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EC | 3.5.1.89 | ||||||||||||
Accepted name: | N-acetylglucosaminylphosphatidylinositol deacetylase | ||||||||||||
Reaction: | 6-(N-acetyl-α-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O = 6-(α-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate | ||||||||||||
For diagram of glycosylphosphatidyl-myo-inositol biosynthesis, click here | |||||||||||||
Other name(s): | N-acetyl-D-glucosaminylphosphatidylinositol acetylhydrolase; N-acetylglucosaminylphosphatidylinositol de-N-acetylase; GlcNAc-PI de-N-acetylase; GlcNAc-PI deacetylase; acetylglucosaminylphosphatidylinositol deacetylase | ||||||||||||
Systematic name: | 6-(N-acetyl-α-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol acetylhydrolase | ||||||||||||
Comments: | Involved in the second step of glycosylphosphatidylinositol (GPI) anchor formation in all eukaryotes. The enzyme appears to be composed of a single subunit (PIG-L in mammalian cells and GPI12 in yeast). In some species, the long-chain sn-1-acyl group of the phosphatidyl group is replaced by a long-chain alkyl or alk-1-enyl group. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 122191-30-4 | ||||||||||||
References: |
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EC | 4.6.1.13 | ||||||||||||
Accepted name: | phosphatidylinositol diacylglycerol-lyase | ||||||||||||
Reaction: | 1-phosphatidyl-1D-myo-inositol = 1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol | ||||||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism, click here | |||||||||||||
Other name(s): | monophosphatidylinositol phosphodiesterase; phosphatidylinositol phospholipase C; 1-phosphatidylinositol phosphodiesterase; 1-phosphatidyl-D-myo-inositol inositolphosphohydrolase (cyclic-phosphate-forming); 1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming) | ||||||||||||
Systematic name: | 1-phosphatidyl-1D-myo-inositol 1,2-diacyl-sn-glycerol-lyase (1D-myo-inositol-1,2-cyclic-phosphate-forming) | ||||||||||||
Comments: | This enzyme is bacterial. Activity is also found in animals, but this activity is due to the presence of EC 3.1.4.11, phosphoinositide phospholipase C. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37288-19-0 | ||||||||||||
References: |
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EC | 4.6.1.14 | ||||||||||||
Accepted name: | glycosylphosphatidylinositol diacylglycerol-lyase | ||||||||||||
Reaction: | 6-(α-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol = 6-(α-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol | ||||||||||||
For diagram of glycosylphosphatidyl-myo-inositol biosynthesis, click here | |||||||||||||
Other name(s): | (glycosyl)phosphatidylinositol-specific phospholipase C; GPI-PLC; GPI-specific phospholipase C; VSG-lipase; glycosyl inositol phospholipid anchor-hydrolyzing enzyme; glycosylphosphatidylinositol-phospholipase C; glycosylphosphatidylinositol-specific phospholipase C; variant-surface-glycoprotein phospholipase C; 6-(α-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming) | ||||||||||||
Systematic name: | 6-(α-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol 1,2-diacyl-sn-glycerol-lyase [6-(α-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate-forming] | ||||||||||||
Comments: | This enzyme is also active when O-4 of the glucosamine is substituted by carrying the oligosaccharide that can link a protein to the structure. It therefore cleaves proteins from the lipid part of the glycosylphostphatidylinositol (GPI) anchors. In some cases, the long-chain acyl group at the sn-1 position of glycerol is replaced by an alkyl or alk-1-enyl group. In other cases, the diacylglycerol is replaced by ceramide (see Lip-1.4 and Lip-1.5 for definition). The only characterized enzyme with this specificity is from Trypanosoma brucei, where the acyl groups are myristoyl, but the function of the trypanosome enzyme is unknown. Substitution on O-2 of the inositol blocks action of this enzyme. It is not identical with EC 3.1.4.50, glycosylphosphatidylinositol phospholipase D. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 129070-68-4 | ||||||||||||
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