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Your query returned 8 entries. Printable version
EC | 2.7.1.68 | ||||||||
Accepted name: | 1-phosphatidylinositol-4-phosphate 5-kinase | ||||||||
Reaction: | ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | ||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism (part 2), click here | |||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol = PtdIns 1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P 1-phosphatidyl-1D-myo-inositol 4-phosphate = PtdIns4P 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate = PtdIns(3,4)P2 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = PtdIns(4,5)P2 |
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Other name(s): | diphosphoinositide kinase; PIP kinase; phosphatidylinositol 4-phosphate kinase; phosphatidylinositol-4-phosphate 5-kinase; type I PIP kinase | ||||||||
Systematic name: | ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase | ||||||||
Comments: | This enzyme can also phosphorylate PtdIns3P in the 4-position, and PtdIns, PtdIns3P and PtdIns(3,4)P2 in the 5-position in vitro, but to a lesser extent. The last of these reactions occurs in vivo and is physiologically relevant. Three different isoforms are known. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 104645-76-3 | ||||||||
References: |
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EC | 2.7.1.137 | ||||||||
Accepted name: | phosphatidylinositol 3-kinase | ||||||||
Reaction: | ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate | ||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism, click here | |||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol = PtdIns 1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P |
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Other name(s): | 1-phosphatidylinositol 3-kinase; type III phosphoinositide 3-kinase; Vps34p; type I phosphatidylinositol kinase | ||||||||
Systematic name: | ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase | ||||||||
Comments: | One mammalian isoform is known. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 115926-52-8 | ||||||||
References: |
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EC | 2.7.1.150 | ||||||||
Accepted name: | 1-phosphatidylinositol-3-phosphate 5-kinase | ||||||||
Reaction: | ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate | ||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism, click here | |||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate = PtdIns(3,5)P2 |
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Other name(s): | type III PIP kinase; phosphatidylinositol 3-phosphate 5-kinase | ||||||||
Systematic name: | ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||
References: |
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EC | 2.7.1.153 | ||||||||
Accepted name: | phosphatidylinositol-4,5-bisphosphate 3-kinase | ||||||||
Reaction: | ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate | ||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism (part 2), click here | |||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol = PtdIns 1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P 1-phosphatidyl-1D-myo-inositol 4-phosphate = PtdIns4P 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate = PtdIns(3,4)P2 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = PtdIns(4,5)P2 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate = PtdIns(3,4,5)P3 |
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Other name(s): | type I phosphoinositide 3-kinase | ||||||||
Systematic name: | ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase | ||||||||
Comments: | This enzyme also catalyses the phosphorylation of PtdIns4P to PtdIns(3,4)P2, and of PtdIns to PtdIns3P. Four mammalian isoforms are known to exist. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 103843-30-7 | ||||||||
References: |
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EC | 2.7.1.154 | ||||||||
Accepted name: | phosphatidylinositol-4-phosphate 3-kinase | ||||||||
Reaction: | ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate | ||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism, click here | |||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol = PtdIns 1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P 1-phosphatidyl-1D-myo-inositol 4-phosphate = PtdIns4P 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate = PtdIns(3,4)P2 |
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Other name(s): | type II phosphoinositide 3-kinase; C2-domain-containing phosphoinositide 3-kinase; phosphoinositide 3-kinase | ||||||||
Systematic name: | ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase | ||||||||
Comments: | This enzyme also phosphorylates PtdIns to PtdIns3P. Three mammalian isoforms have been found to date. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 141176-94-5 | ||||||||
References: |
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EC | 3.1.3.64 | ||||||||
Accepted name: | phosphatidylinositol-3-phosphatase | ||||||||
Reaction: | 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate | ||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism, click here | |||||||||
Glossary: | inositol 1-phosphate = Ins-1-P inositol 1,3-bisphosphate = Ins(1,3)P2 1-phosphatidyl-1D-myo-inositol = PtdIns 1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P |
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Other name(s): | inositol-1,3-bisphosphate 3-phosphatase; inositol 1,3-bisphosphate phosphatase; inositol-polyphosphate 3-phosphatase; D-myo-inositol-1,3-bisphosphate 3-phosphohydrolase; phosphatidyl-3-phosphate 3-phosphohydrolase | ||||||||
Systematic name: | 1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase | ||||||||
Comments: | This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3)P2 to Ins-1-P. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 124248-47-1 | ||||||||
References: |
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EC | 3.1.3.66 | ||||||||
Accepted name: | phosphatidylinositol-3,4-bisphosphate 4-phosphatase | ||||||||
Reaction: | 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate | ||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism, click here | |||||||||
Glossary: | inositol 3-phosphate = Ins-3-P inositol 1,3-bisphosphate = Ins(1,3)P2 inositol 3,4-bisphosphate = Ins(3,4)P2 inositol 1,3,4-trisphosphate = Ins(1,3,4)P3 1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P 1-phosphatidyl-1D-myo-inositol 4-phosphate = PtdIns4P |
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Other name(s): | inositol-3,4-bisphosphate 4-phosphatase; D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase; phosphoinositide 4-phosphatase; inositol polyphosphate 4-phosphatase; inositol polyphosphate 4-phosphatase type II | ||||||||
Systematic name: | 1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase | ||||||||
Comments: | Mg2+-independent. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3,4)P3 to Ins(1,3)P2. It also converts Ins(3,4)P2 into Ins-3-P. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 123644-80-4 | ||||||||
References: |
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EC | 3.1.3.78 | ||||||||
Accepted name: | phosphatidylinositol-4,5-bisphosphate 4-phosphatase | ||||||||
Reaction: | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate | ||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P 1-phosphatidyl-1D-myo-inositol 4-phosphate = PtdIns4P 1-phosphatidyl-1D-myo-inositol 5-phosphate = PtdIns5P 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate = PtdIns(3,4)P2 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate = PtdIns(3,5)P2 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = PtdIns(4,5)P2 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate = PtdIns(3,4,5)P3 |
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Other name(s): | phosphatidylinositol-4,5-bisphosphate 4-phosphatase I; phosphatidylinositol-4,5-bisphosphate 4-phosphatase II; type I PtdIns-4,5-P2 4-Ptase; type II PtdIns-4,5-P2 4-Ptase; IpgD; PtdIns-4,5-P2 4-phosphatase type I; PtdIns-4,5-P2 4-phosphatase type II; type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase; type 1 4-phosphatase | ||||||||
Systematic name: | 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase | ||||||||
Comments: | Two pathways exist in mammalian cells to degrade 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2] [2]. One is catalysed by this enzyme and the other by EC 3.1.3.36, phosphoinositide 5-phosphatase, where the product is PtdIns4P. The enzyme from human is specific for PtdIns(4,5)P2 as substrate, as it cannot use PtdIns(3,4,5)P3, PtdIns(3,4)P2, PtdIns(3,5)P2, PtdIns5P, PtdIns4P or PtdIns3P [2]. In humans, the enzyme is localized to late endosomal/lysosomal membranes [2]. It can control nuclear levels of PtdIns5P and thereby control p53-dependent apoptosis [3]. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||
References: |
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