EC |
2.3.1.218 |
Accepted name: |
phenylpropanoylacetyl-CoA synthase |
Reaction: |
(1) feruloyl-CoA + malonyl-CoA = feruloylacetyl-CoA + CO2 + CoA (2) 4-coumaroyl-CoA + malonyl-CoA = (4-coumaroyl)acetyl-CoA + CO2 + CoA |
Glossary: |
feruloylacetyl-CoA = feruloyl-diketide-CoA
(4-coumaroyl)acetyl-CoA = 4-coumaroyl-diketide-CoA
phenylpropanoylacetyl-CoA = phenylpropanoyl-diketide-CoA |
Other name(s): |
phenylpropanoyl-diketide-CoA synthase; DCS |
Systematic name: |
phenylpropanoyl-CoA:malonyl-CoA phenylpropanoyl-transferase (decarboxylating) |
Comments: |
The enzyme has been characterized from the plant Curcuma longa (turmeric). It prefers feruloyl-CoA, and has no activity with cinnamoyl-CoA. |
References: |
1. |
Katsuyama, Y., Kita, T., Funa, N. and Horinouchi, S. Curcuminoid biosynthesis by two type III polyketide synthases in the herb Curcuma longa. J. Biol. Chem. 284 (2009) 11160–11170. [PMID: 19258320] |
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[EC 2.3.1.218 created 2013] |
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EC |
2.3.1.219 |
Accepted name: |
demethoxycurcumin synthase |
Reaction: |
(1) 4-coumaroyl-CoA + feruloylacetyl-CoA + H2O = 2 CoA + demethoxycurcumin + CO2 (2) 4-coumaroyl-CoA + (4-coumaroyl)acetyl-CoA + H2O = 2 CoA + bisdemethoxycurcumin + CO2 |
Glossary: |
demethoxycurcumin = (1E,6E)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,4,6-trien-3-one
bisdemethoxycurcumin = (1E,6E)-5-hydroxy-1,7-bis(4-hydroxyphenyl)hepta-1,4,6-trien-3-one
feruloylacetyl-CoA = feruloyl-diketide-CoA
(4-coumaroyl)acetyl-CoA = 4-coumaroyl-diketide-CoA |
Other name(s): |
CURS3 |
Systematic name: |
4-coumaroyl-CoA:feruloylacetyl-CoA feruloyltransferase (demethoxycurcumin-forming) |
Comments: |
A polyketide synthase from the plant Curcuma longa (turmeric). Three isoforms exist, CURS1, CURS2 and CURS3. While CURS1 and CURS2 prefer feruloyl-CoA as a starter substrate (cf. EC 2.3.1.217, curcumin synthase), CURS3 can accept 4-coumaroyl-CoA equally well [1]. |
References: |
1. |
Katsuyama, Y., Kita, T. and Horinouchi, S. Identification and characterization of multiple curcumin synthases from the herb Curcuma longa. FEBS Lett. 583 (2009) 2799–2803. [PMID: 19622354] |
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[EC 2.3.1.219 created 2013] |
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