EC |
2.3.1.245 |
Accepted name: |
3-hydroxy-5-phosphooxypentane-2,4-dione thiolase |
Reaction: |
glycerone phosphate + acetyl-CoA = 3-hydroxy-2,4-dioxopentyl phosphate + CoA |
Glossary: |
(4S)-4,5-dihydroxypentane-2,3-dione = autoinducer 2 = AI-2 |
Other name(s): |
lsrF (gene name); 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase |
Systematic name: |
acetyl-CoA:glycerone phosphate C-acetyltransferase |
Comments: |
The enzyme participates in a degradation pathway of the bacterial quorum-sensing autoinducer molecule AI-2. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
References: |
1. |
Diaz, Z., Xavier, K.B. and Miller, S.T. The crystal structure of the Escherichia coli autoinducer-2 processing protein LsrF. PLoS One 4:e6820 (2009). [DOI] [PMID: 19714241] |
2. |
Marques, J.C., Oh, I.K., Ly, D.C., Lamosa, P., Ventura, M.R., Miller, S.T. and Xavier, K.B. LsrF, a coenzyme A-dependent thiolase, catalyzes the terminal step in processing the quorum sensing signal autoinducer-2. Proc. Natl. Acad. Sci. USA 111 (2014) 14235–14240. [DOI] [PMID: 25225400] |
|
[EC 2.3.1.245 created 2015, modified 2021] |
|
|
|
|
EC |
5.3.1.32 |
Accepted name: |
(4S)-4-hydroxy-5-phosphooxypentane-2,3-dione isomerase |
Reaction: |
(2S)-2-hydroxy-3,4-dioxopentyl phosphate = 3-hydroxy-2,4-dioxopentyl phosphate |
Glossary: |
(2S)-2-hydroxy-3,4-dioxopentyl phosphate = (4S)-4-hydroxy-5-phosphooxypentane-2,3-dione
(4S)-4,5-dihydroxypentane-2,3-dione = autoinducer 2 = AI-2 |
Other name(s): |
lsrG (gene name); phospho-AI-2 isomerase; (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione aldose-ketose-isomerase; (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase; (4S)-4-hydroxy-5-phosphooxypentane-2,3-dione aldose-ketose-isomerase |
Systematic name: |
(2S)-2-hydroxy-3,4-dioxopentyl phosphate aldose-ketose-isomerase |
Comments: |
The enzyme participates in a degradation pathway of the bacterial quorum-sensing autoinducer molecule AI-2. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
References: |
1. |
Xavier, K.B., Miller, S.T., Lu, W., Kim, J.H., Rabinowitz, J., Pelczer, I., Semmelhack, M.F. and Bassler, B.L. Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria. ACS Chem. Biol. 2 (2007) 128–136. [DOI] [PMID: 17274596] |
2. |
Marques, J.C., Lamosa, P., Russell, C., Ventura, R., Maycock, C., Semmelhack, M.F., Miller, S.T. and Xavier, K.B. Processing the interspecies quorum-sensing signal autoinducer-2 (AI-2): characterization of phospho-(S)-4,5-dihydroxy-2,3-pentanedione isomerization by LsrG protein. J. Biol. Chem. 286 (2011) 18331–18343. [DOI] [PMID: 21454635] |
|
[EC 5.3.1.32 created 2015] |
|
|
|
|