EC |
4.2.3.136 |
Accepted name: |
α-isocomene synthase |
Reaction: |
(2E,6E)-farnesyl diphosphate = (-)-α-isocomene + diphosphate |
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For diagram of bicyclic and tricyclic sesquiterpenoids derived from humuladienyl cation, click here and for mechanism, click here |
Glossary: |
(-)-α-isocomene = (1R,3aS,5aS,8aR)-1,3a,4,5a-tetramethyl-1,2,3,3a,5a,6,7,8-octahydrocyclopenta[c]pentalene |
Other name(s): |
MrTPS2 |
Systematic name: |
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (-)-α-isocomene-forming) |
Comments: |
Isolated from the roots of the plant Matricaria chamomilla var. recutita (chamomile). The enzyme also produced traces of five other sesquiterpenoids. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Irmisch, S., Krause, S.T., Kunert, G., Gershenzon, J., Degenhardt, J. and Kollner, T.G. The organ-specific expression of terpene synthase genes contributes to the terpene hydrocarbon composition of chamomile essential oils. BMC Plant Biol. 12:84 (2012). [DOI] [PMID: 22682202] |
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[EC 4.2.3.136 created 2012] |
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