The Enzyme Database

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EC 7.2.2.4     
Accepted name: ABC-type Na+ transporter
Reaction: ATP + H2O + Na+[side 1] = ADP + phosphate + Na+[side 2]
Other name(s): natAB (gene names)
Systematic name: ATP phosphohydrolase (ABC-type, Na+-exporting)
Comments: ABC-type (ATP-binding cassette-type) transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. This bacterial enzyme, characterized from Bacillus subtilis, exports Na+ ions out of the cell. cf. EC 7.2.2.1, Na+-transporting two-sector ATPase and EC 7.2.2.3, P-type Na+ transporter.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Cheng, J., Guffanti, A.A. and Krulwich, T.A. A two-gene ABC-type transport system that extrudes Na+ in Bacillus subtilis is induced by ethanol or protonophore. Mol. Microbiol. 23 (1997) 1107–1120. [DOI] [PMID: 9106203]
2.  Ogura, M., Tsukahara, K., Hayashi, K. and Tanaka, T. The Bacillus subtilis NatK-NatR two-component system regulates expression of the natAB operon encoding an ABC transporter for sodium ion extrusion. Microbiology 153 (2007) 667–675. [PMID: 17322186]
[EC 7.2.2.4 created 2018]
 
 


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