EC |
7.2.2.3 |
Accepted name: |
P-type Na+ transporter |
Reaction: |
ATP + H2O + Na+[side 1] = ADP + phosphate + Na+[side 2] |
Other name(s): |
Na+-exporting ATPase (ambiguous); ENA1 (gene name); ENA2 (gene name); ENA5 (gene name); sodium transport ATPase (ambiguous); sodium-translocating P-type ATPase |
Systematic name: |
ATP phosphohydrolase (P-type, Na+-exporting) |
Comments: |
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme from yeast is involved in the efflux of Na+, with one ion being exported per ATP hydrolysed. Some forms can also export Li+ ions. cf. EC 7.2.2.1, Na+-transporting two-sector ATPase and EC 7.2.2.4, ABC-type Na+ transporter. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Wieland, J., Nitsche, A.M., Strayle, J., Steiner, H. and Rudolph, H.K. The PMR2 gene cluster encodes functionally distinct isoforms of a putative Na+ pump in the yeast plasma membrane. EMBO J. 14 (1995) 3870–3882. [PMID: 7664728] |
2. |
Catty, P., de Kerchove d'Exaerde, A. and Goffeau, A. The complete inventory of the yeast Saccharomyces cerevisiae P-type transport ATPases. FEBS Lett. 409 (1997) 325–332. [DOI] [PMID: 9224683] |
3. |
Benito, B., Quintero, F.J. and Rodriguez-Navarro, A. Overexpression of the sodium ATPase of Saccharomyces cerevisiae: conditions for phosphorylation from ATP and Pi. Biochim. Biophys. Acta 1328 (1997) 214–226. [PMID: 9315618] |
4. |
Saier, M.H., Jr. Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya. Adv. Microb. Physiol. 40 (1998) 81–136. [PMID: 9889977] |
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[EC 7.2.2.3 created 2000 as EC 3.6.3.7, modified 2001, transferred 20018 to EC 7.2.2.3] |
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