| EC |
6.5.1.1 |
| Accepted name: |
DNA ligase (ATP) |
| Reaction: |
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)n+m |
| Other name(s): |
polydeoxyribonucleotide synthase (ATP); polynucleotide ligase; sealase; DNA repair enzyme; DNA joinase; DNA ligase; deoxyribonucleic ligase; deoxyribonucleate ligase; DNA-joining enzyme; deoxyribonucleic-joining enzyme; deoxyribonucleic acid-joining enzyme; deoxyribonucleic repair enzyme; deoxyribonucleic joinase; deoxyribonucleic acid ligase; deoxyribonucleic acid joinase; deoxyribonucleic acid repair enzyme |
| Systematic name: |
poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming) |
| Comments: |
Catalyses the formation of a phosphodiester at the site of a single-strand break in duplex DNA. RNA can also act as substrate, to some extent. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, METACYC, PDB, CAS registry number: 9015-85-4 |
| References: |
| 1. |
Becker, A., Lyn, G., Gefter, M. and Hurwitz, J. The enzymatic repair of DNA. II. Characterization of phage-induced sealase. Proc. Natl. Acad. Sci. USA 58 (1967) 1996–2003. [PMID: 4295584] |
| 2. |
Bertazzoni, U., Mathelet, M. and Campagnari, F. Purification and properties of a polynucleotide ligase from calf thymus glands. Biochim. Biophys. Acta 287 (1972) 404–414. [PMID: 4641251] |
| 3. |
Weiss, B. and Richardson, C.C. Enzymatic breakage and joining of deoxyribonucleic acid. I. Repair of single-strand breaks in DNA by an enzyme system from Escherichia coli infected with T4 bacteriophage. Proc. Natl. Acad. Sci. USA 57 (1967) 1021–1028. [PMID: 5340583] |
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| [EC 6.5.1.1 created 1972, modified 1976] |
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