| EC |
6.4.1.3 |
| Accepted name: |
propionyl-CoA carboxylase |
| Reaction: |
ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA |
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For diagram of the 3-hydroxypropanoate cycle, click here |
| Other name(s): |
propionyl coenzyme A carboxylase |
| Systematic name: |
propanoyl-CoA:carbon-dioxide ligase (ADP-forming) |
| Comments: |
A biotinyl-protein. Also carboxylates butanoyl-CoA and catalyses transcarboxylation. |
| Links to other databases: |
BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9023-94-3 |
| References: |
| 1. |
Kaziro, Y., Ochoa, S., Warner, R.C. and Chen, J.-Y. Metabolism of propionic acid in animal tissues. VIII. Crystalline propionyl carboxylase. J. Biol. Chem. 236 (1961) 1917–1923. [PMID: 13752080] |
| 2. |
Lane, M.D., Halenz, D.R., Kosow, D.P. and Hegre, C.S. Further studies on mitochondrial propionyl carboxylase. J. Biol. Chem. 235 (1960) 3082–3086. [PMID: 13758723] |
| 3. |
Meyer, H., Nevaldine, B. and Meyer, F. Acyl-coenzyme A carboxylase of the free-living nematode Turbatrix aceti. 1. Its isolation and molecular characteristics. Biochemistry 17 (1978) 1822–1827. [PMID: 656363] |
| 4. |
Moss, J. and Lane, M.D. The biotin-dependent enzymes. Adv. Enzymol. Relat. Areas Mol. Biol. 35 (1971) 321–442. [PMID: 4150153] |
| 5. |
Vagelos, P. Regulation of fatty acid biosynthesis. Curr. Top. Cell. Regul. 4 (1971) 119–166. |
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| [EC 6.4.1.3 created 1961, modified 1983] |
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