The Enzyme Database

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EC 6.4.1.2     
Accepted name: acetyl-CoA carboxylase
Reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA
For diagram of the 3-hydroxypropanoate cycle, click here
Other name(s): acetyl coenzyme A carboxylase
Systematic name: acetyl-CoA:carbon-dioxide ligase (ADP-forming)
Comments: A biotinyl-protein. Also catalyses transcarboxylation; the plant enzyme also carboxylates propanonyl-CoA and butanoyl-CoA.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9023-93-2
References:
1.  Hatch, M.D. and Stumpf, P.K. Fat metabolism in higher plants. XVI. Acetyl coenzyme A carboxylase and acyl coenzyme A-malonyl coenzyme A transcarboxylase from wheat germ. J. Biol. Chem. 236 (1961) 2879–2885. [PMID: 13905314]
2.  Matsuhashi, M., Matsuhashi, S. and Lynen, F. Zur Biosynthese der Fettsäuren. V. Die Acetyl-CoA Carboxylase aus Rattenleber und ihre Aktivierung durch Citronsäure. Biochem. Z. 340 (1964) 263–289. [PMID: 14317958]
3.  Matsuhashi, M., Matsuhashi, S., Numa, S. and Lynen, F. [On the biosynthesis of fatty acids. IV. Acetyl-CoA carboxylase from yeast.] Biochem. Z. 340 (1964) 243–262. [PMID: 14317957]
4.  Vagelos, P. Regulation of fatty acid biosynthesis. Curr. Top. Cell. Regul. 4 (1971) 119–166.
5.  Wakil, S.J. A malonic acid derivative as an intermediate in fatty acid synthesis. J. Am. Chem. Soc. 80 (1958) 6465.
[EC 6.4.1.2 created 1961]
 
 


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