| EC |
6.3.5.2 |
| Accepted name: |
GMP synthase (glutamine-hydrolysing) |
| Reaction: |
ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate |
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For diagram of AMP and GMP biosynthesis, click here |
| Glossary: |
XMP = xanthosine 5′-phosphate |
| Other name(s): |
GMP synthetase (glutamine-hydrolysing); guanylate synthetase (glutamine-hydrolyzing); guanosine monophosphate synthetase (glutamine-hydrolyzing); xanthosine 5′-phosphate amidotransferase; guanosine 5′-monophosphate synthetase |
| Systematic name: |
xanthosine-5′-phosphate:L-glutamine amido-ligase (AMP-forming) |
| Links to other databases: |
BRENDA, EXPASY, KEGG, METACYC, PDB, CAS registry number: 37318-71-1 |
| References: |
| 1. |
Abrams, R. and Bentley, M. Biosynthesis of nucleic acid purines. III. Guanosine 5′-phosphate formation from xanthosine 5′-phosphate and L-glutamine. Arch. Biochem. Biophys. 79 (1959) 91–110. |
| 2. |
Lagerkvist, U. Biosynthesis of guanosine 5′-phosphate. II. Amination of xanthosine 5′-phosphate by purified enzyme from pigeon liver. J. Biol. Chem. 233 (1958) 143–149. [PMID: 13563458] |
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| [EC 6.3.5.2 created 1961] |
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