EC |
6.3.5.1 |
Accepted name: |
NAD+ synthase (glutamine-hydrolysing) |
Reaction: |
ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate |
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For diagram of NAD+ biosynthesis, click here |
Other name(s): |
NAD synthetase (glutamine-hydrolysing); nicotinamide adenine dinucleotide synthetase (glutamine); desamidonicotinamide adenine dinucleotide amidotransferase; DPN synthetase |
Systematic name: |
deamido-NAD+:L-glutamine amido-ligase (AMP-forming) |
Comments: |
NH3 can act instead of glutamine (cf. EC 6.3.1.5 NAD+ synthase). |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37318-70-0 |
References: |
1. |
Imsande, J. Pathway of diphosphopyridine nucleotide biosynthesis in Escherichia coli. J. Biol. Chem. 236 (1961) 1494–1497. [PMID: 13717628] |
2. |
Imsande, J. and Handler, P. Biosynthesis of diphosphopyridine nucleotide. III. Nicotinic acid mononucleotide pyrophosphorylase. J. Biol. Chem. 236 (1961) 525–530. [PMID: 13717627] |
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[EC 6.3.5.1 created 1961] |
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