The Enzyme Database

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EC 6.3.5.1     
Accepted name: NAD+ synthase (glutamine-hydrolysing)
Reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate
For diagram of NAD+ biosynthesis, click here
Other name(s): NAD synthetase (glutamine-hydrolysing); nicotinamide adenine dinucleotide synthetase (glutamine); desamidonicotinamide adenine dinucleotide amidotransferase; DPN synthetase
Systematic name: deamido-NAD+:L-glutamine amido-ligase (AMP-forming)
Comments: NH3 can act instead of glutamine (cf. EC 6.3.1.5 NAD+ synthase).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37318-70-0
References:
1.  Imsande, J. Pathway of diphosphopyridine nucleotide biosynthesis in Escherichia coli. J. Biol. Chem. 236 (1961) 1494–1497. [PMID: 13717628]
2.  Imsande, J. and Handler, P. Biosynthesis of diphosphopyridine nucleotide. III. Nicotinic acid mononucleotide pyrophosphorylase. J. Biol. Chem. 236 (1961) 525–530. [PMID: 13717627]
[EC 6.3.5.1 created 1961]
 
 


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