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Accepted name: urea carboxylase
Reaction: ATP + urea + HCO
= ADP + phosphate + urea-1-carboxylate 3 -
Glossary: urea-1-carboxylate = allophanate
Other name(s): urease (ATP-hydrolysing); urea carboxylase (hydrolysing); ATP—urea amidolyase; urea amidolyase; UALase; UCA
Systematic name: urea:carbon-dioxide ligase (ADP-forming)
Comments: A biotinyl-protein. The yeast enzyme (but not that from green algae) also catalyses the reaction of
EC 18.104.22.168 allophanate hydrolase, thus bringing about the hydrolysis of urea to CO and NH 2 . Previously also listed as EC 22.214.171.124. The enzyme from the prokaryotic bacterium 3 Oleomonas sagaranensis can also use acetamide and formamide as substrates .
Links to other databases:
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9058-98-4
Roon, R.J. and Levenberg, B. ATP-Urea amidolyase (ADP) (
Candida utilis). Methods Enzymol. 17A (1970) 317–324.
Roon, R.J. and Levenberg, B. Urea amidolyase. I. Properties of the enzyme from
Candida utilis. J. Biol. Chem. 247 (1972) 4107–4113. [PMID: 4556303]
Sumrada, R.A. and Cooper, T.G. Urea carboxylase and allophanate hydrolase are components of a multifunctional protein in yeast.
J. Biol. Chem. 257 (1982) 9119–9127. [PMID: 6124544]
Kanamori, T., Kanou, N., Atomi, H. and Imanaka, T. Enzymatic characterization of a prokaryotic urea carboxylase.
J. Bacteriol. 186 (2004) 2532–2539. [ DOI] [PMID: 15090492]
[EC 126.96.36.199 created 1972, modified 1986 (EC 188.8.131.52 created 1978, incorporated 1986)]
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