The Enzyme Database

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EC 6.3.4.4     
Accepted name: adenylosuccinate synthase
Reaction: GTP + IMP + L-aspartate = GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP
For diagram of AMP and GMP biosynthesis, click here
Other name(s): IMP—aspartate ligase; adenylosuccinate synthetase; succinoadenylic kinosynthetase; succino-AMP synthetase
Systematic name: IMP:L-aspartate ligase (GDP-forming)
Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9023-57-8
References:
1.  Davey, C.L. Synthesis of adenylosuccinic acid in preparations of mammalian skeletal muscle. Nature 183 (1959) 995–996. [PMID: 13644270]
2.  Lieberman, I. Enzymatic synthesis of adenosine-5′-phosphate from inosine-5′-phosphate. J. Biol. Chem. 223 (1956) 327–339. [PMID: 13376602]
3.  Yefimochkina, E.F. and Braunstein, A.E. The amination of inosinic acid to adenylic acid in muscle extracts. Arch. Biochem. Biophys. 83 (1959) 350–352. [PMID: 13662023]
[EC 6.3.4.4 created 1961]
 
 


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