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Accepted name: aerobactin synthase
2 ATP + N -citryl- 2 N -acetyl- 6 N -hydroxy- 6 L-lysine + N -acetyl- 6 N -hydroxy- 6 L-lysine + H O = 2 2 ADP + 2 phosphate + aerobactin
For diagram of aerobactin biosynthesis,
iucC ( gene name)
N -citryl- 2 N -acetyl- 6 N -hydroxy- 6 L-lysine: N -acetyl- 6 N -hydroxy- 6 L-lysine ligase (ADP-forming)
Comments: Requires Mg
. Aerobactin is one of a group of high-affinity iron chelators known as siderophores and is produced under conditions of iron deprivation . It is a dihydroxamate comprising two molecules of 2+ N -acetyl- 6 N -hydroxy- 6 L-lysine and one molecule of citric acid. This enzyme catalyses the second of two synthase reactions to link N -acetyl- 6 N -hydroxy- 6 L-lysine and citrate [3,4,5].
Links to other databases:
BRENDA, EXPASY, KEGG, MetaCyc
Appanna, D.L., Grundy, B.J., Szczepan, E.W. and Viswanatha, T. Aerobactin synthesis in a cell-free system of
Aerobacter aerogenes 62-1. Biochim. Biophys. Acta 801 (1984) 437–443.
Gibson, F. and Magrath, D.I. The isolation and characterization of a hydroxamic acid (aerobactin) formed by
Aerobacter aerogenes 62-I. Biochim. Biophys. Acta 192 (1969) 175–184. [PMID: 4313071]
Maurer, P.J. and Miller, M. Microbial iron chelators: total synthesis of aerobactin and its constituent amino acid,
N -acetyl- 6 N -hydroxylysine. 6 J. Am. Chem. Soc. 104 (1982) 3096–3101.
de Lorenzo, V., Bindereif, A., Paw, B.H. and Neilands, J.B. Aerobactin biosynthesis and transport genes of plasmid ColV-K30 in
Escherichia coli K-12. J. Bacteriol. 165 (1986) 570–578. [PMID: 2935523]
de Lorenzo, V. and Neilands, J.B. Characterization of
iucA and iucC genes of the aerobactin system of plasmid ColV-K30 in Escherichia coli. J. Bacteriol. 167 (1986) 350–355. [PMID: 3087960]
Challis, G.L. A widely distributed bacterial pathway for siderophore biosynthesis
independent of nonribosomal peptide synthetases.
ChemBioChem 6 (2005) 601–611. [PMID: 15719346]
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