The Enzyme Database

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EC 6.3.1.2     
Accepted name: glutamate—ammonia ligase
Reaction: ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine
Other name(s): glutamine synthetase; glutamylhydroxamic synthetase; L-glutamine synthetase
Systematic name: L-glutamate:ammonia ligase (ADP-forming)
Comments: Also acts, more slowly, on 4-methylene-L-glutamate (cf. EC 6.3.1.7 4-methyleneglutamate—ammonia ligase).
Links to other databases: BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, PDB, CAS registry number: 9023-70-5
References:
1.  Elliott, W.H. Isolation of glutamine synthetase and glutamotransferase from green peas. J. Biol. Chem. 201 (1953) 661–672. [PMID: 13061404]
2.  Fry, B.A. Glutamine synthesis by Micrococcus pyogenes var. aureus. Biochem. J. 59 (1955) 579–589. [PMID: 14363150]
3.  Lajtha, A., Mela, P. and Waelsch, H. Manganese-dependent glutamotransferase. J. Biol. Chem. 205 (1953) 553–564. [PMID: 13129232]
4.  Meister, A. Glutamine synthesis. In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds), The Enzymes, 2nd edn, vol. 6, Academic Press, New York, 1962, pp. 443–468.
5.  Woolfolk, C.A., Shapiro, B. and Stadtman, E.R. Regulation of glutamine synthetase. I. Purification and properties of glutamine synthetase from Escherichia coli. Arch. Biochem. Biophys. 116 (1966) 177–192. [PMID: 5336023]
[EC 6.3.1.2 created 1961]
 
 


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