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Your query returned 1 entry. Printable version
EC | 6.2.1.61 | ||||
Accepted name: | salicylate—[aryl-carrier protein] ligase | ||||
Reaction: | ATP + salicylate + holo-[non-ribosomal peptide synthase] = AMP + diphosphate + salicyl-[non-ribosomal peptide synthase] (overall reaction) (1a) ATP + salicylate = diphosphate + (salicyl)adenylate (1b) (salicyl)adenylate + holo-[non-ribosomal peptide synthase] = AMP + salicyl-[non-ribosomal peptide synthase] |
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Other name(s): | pmsE (gene name); pchD (gene name) | ||||
Systematic name: | salicylate:holo-[non-ribosomal peptide synthase] ligase | ||||
Comments: | The enzyme catalyses the activation of salicylate to (salicyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of an aryl-carrier protein, which is often a domain of a larger non-ribosimal peptide synthase. The PmsE enzyme is involved in pseudomonine biosynthesis and transfers the activated salicylate first to itself, and then to a PmsG protein. The PchD enzyme is involved in pyochelin biosynthesis and transfers the activated salicylate directly to the PchE protein. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||
References: |
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