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Your query returned 1 entry. Printable version
EC | 6.2.1.52 | ||||||||
Accepted name: | L-firefly luciferin—CoA ligase | ||||||||
Reaction: | ATP + L-firefly luciferin + CoA = AMP + diphosphate + L-firefly luciferyl-CoA | ||||||||
Glossary: | L-firefly luciferin = (R)-4,5-dihydro-2-(6-hydroxy-1,3-benzothiazol-2-yl)thiazole-4-carboxylate | ||||||||
Other name(s): | LUC | ||||||||
Systematic name: | (R)-4,5-dihydro-2-(6-hydroxy-1,3-benzothiazol-2-yl)thiazole-4-carboxylate:CoA ligase (AMP-forming) | ||||||||
Comments: | This is an alternative activity of the firefly luciferase (EC 1.13.12.7), which the enzyme exhibits under normal conditions only when acting on the L-enantiomer of its substrate. The D-isomer can act as a substrate for the CoA—ligase activity in vitro only under low oxygen conditions that are not found in vivo. The activation of L-firefly luciferin to a CoA ester is a step in a recycling pathway that results in its epimerization to the D enantiomer, which is the only substrate whose oxygenation results in light emission. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||
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