| EC |
5.5.1.7 |
| Accepted name: |
chloromuconate cycloisomerase |
| Reaction: |
2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate |
|
For diagram of reaction, click here |
| Glossary: |
muconolactone = (2,5-dihydro-5-oxofuran-2-yl)acetate
3-chloro-cis,cis-muconate = (2E,4Z)-3-chlorohexa-2,4-dienedioate |
| Other name(s): |
muconate cycloisomerase II |
| Systematic name: |
2-chloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing) |
| Comments: |
Requires Mn2+. The product of cycloisomerization of 3-chloro-cis,cis-muconate spontaneously eliminates chloride to produce cis-4-carboxymethylenebut-2-en-4-olide. Also acts (in the reverse direction) on 2-chloro-cis,cis-muconate. Not identical with EC 5.5.1.1 (muconate cycloisomerase) or EC 5.5.1.11 (dichloromuconate cycloisomerase). |
| Links to other databases: |
BRENDA, EXPASY, KEGG, METACYC, PDB, UM-BBD, CAS registry number: 95990-33-3 |
| References: |
| 1. |
Schmidt, E. and Knackmuss, H.-J. Chemical structure and biodegradability of halogenated aromatic compounds. Conversion of chlorinated muconic acids into maleoylacetic acid. Biochem. J. 192 (1980) 339–347. [PMID: 7305906] |
|
| [EC 5.5.1.7 created 1983] |
| |
|
| |
|
Printable version