The Enzyme Database

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EC 5.5.1.7     
Accepted name: chloromuconate cycloisomerase
Reaction: 2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate
For diagram of reaction, click here
Glossary: muconolactone = (2,5-dihydro-5-oxofuran-2-yl)acetate
3-chloro-cis,cis-muconate = (2E,4Z)-3-chlorohexa-2,4-dienedioate
Other name(s): muconate cycloisomerase II
Systematic name: 2-chloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)
Comments: Requires Mn2+. The product of cycloisomerization of 3-chloro-cis,cis-muconate spontaneously eliminates chloride to produce cis-4-carboxymethylenebut-2-en-4-olide. Also acts (in the reverse direction) on 2-chloro-cis,cis-muconate. Not identical with EC 5.5.1.1 (muconate cycloisomerase) or EC 5.5.1.11 (dichloromuconate cycloisomerase).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, UM-BBD, CAS registry number: 95990-33-3
References:
1.  Schmidt, E. and Knackmuss, H.-J. Chemical structure and biodegradability of halogenated aromatic compounds. Conversion of chlorinated muconic acids into maleoylacetic acid. Biochem. J. 192 (1980) 339–347. [PMID: 7305906]
[EC 5.5.1.7 created 1983]
 
 


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