The Enzyme Database

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EC 5.4.99.63     
Accepted name: ethylmalonyl-CoA mutase
Reaction: (2R)-ethylmalonyl-CoA = (2S)-methylsuccinyl-CoA
Other name(s): Ecm
Systematic name: (2R)-ethylmalonyl-CoA CoA-carbonylmutase
Comments: The enzyme, characterized from the bacterium Rhodobacter sphaeroides, is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation. Requires coenzyme B12 for activity.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Erb, T.J., Retey, J., Fuchs, G. and Alber, B.E. Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases. J. Biol. Chem. 283 (2008) 32283–32293. [PMID: 18819910]
[EC 5.4.99.63 created 2015]
 
 


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