The Enzyme Database

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EC 5.3.99.3     
Accepted name: prostaglandin-E synthase
Reaction: (5Z,13E)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11α,15-dihydroxy-9-oxoprosta-5,13-dienoate
Other name(s): prostaglandin-H2 E-isomerase; endoperoxide isomerase; endoperoxide isomerase; prostaglandin R-prostaglandin E isomerase; prostaglandin endoperoxide E isomerase; PGE isomerase; PGH-PGE isomerase; PGE2 isomerase; prostaglandin endoperoxide E2 isomerase; prostaglandin H-E isomerase
Systematic name: (5Z,13E)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate E-isomerase
Comments: Brings about the opening of the epidioxy bridge. Requires glutathione.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 52227-79-9
References:
1.  Ogino, N., Miyamoto, T., Yamamoto, S. and Hayaishi, O. Prostaglandin endoperoxide E isomerase from bovine vesicular gland microsomes, a glutathione-requiring enzyme. J. Biol. Chem. 252 (1977) 890–895. [PMID: 838703]
2.  Tanaka, Y., Ward, S.L. and Smith, W.L. Immunochemical and kinetic evidence for two different prostaglandin H-prostaglandin E isomerases in sheep vesicular gland microsomes. J. Biol. Chem. 262 (1987) 1374–1381. [PMID: 3100531]
[EC 5.3.99.3 created 1976, modified 1990]
 
 


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