The Enzyme Database

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EC 5.3.99.2     
Accepted name: prostaglandin-D synthase
Reaction: (5Z,13E,15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9α,15-dihydroxy-11-oxoprosta-5,13-dienoate
Other name(s): prostaglandin-H2 Δ-isomerase; prostaglandin-R-prostaglandin D isomerase; PGH-PGD isomerase(5,13)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate Δ-isomerase (incorrect); (5,13)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase; prostaglandin endoperoxide Δ-isomerase; prostaglandin D synthetase
Systematic name: (5Z,13E,15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase
Comments: Brings about the opening of the epidioxy bridge. Some enzymes require glutathione.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 65802-85-9
References:
1.  Christ-Hazelhof, E. and Nugteren, D.H. Purification and characterisation of prostaglandin endoperoxide Δ-isomerase, a cytoplasmic, glutathione-requiring enzyme. Biochim. Biophys. Acta 572 (1979) 43–51. [PMID: 32914]
2.  Shimizu, T., Yamamoto, S. and Hayaishi, O. Purification and properties of prostaglandin D synthetase from rat brain. J. Biol. Chem. 254 (1979) 5222–5228. [PMID: 109431]
[EC 5.3.99.2 created 1976, modified 1990]
 
 


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