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Accepted name: 3-[(4
R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate = 3-[(1 E,4 R)-4-hydroxycyclohex-2-en-1-ylidene]-2-oxopropanoate
For diagram of bacilysin biosynthesis,
L-anticapsin = 3-[(1 R,2 S,6 R)-5-oxo-7-oxabicyclo[4.1.0]hept-2-yl]- L-alanine
Other name(s): BacB
Systematic name: 3-[(4
Comments: The enzyme, characterized from the bacterium
Bacillus subtilis, is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin. The enzyme can interconvert the ( E) isomer formed in the reaction into the ( Z) isomer , although this isomerization is not part of the pathway leading to bacilysin .
Links to other databases:
BRENDA, EXPASY, KEGG, MetaCyc
Mahlstedt, S.A. and Walsh, C.T. Investigation of anticapsin biosynthesis reveals a four-enzyme pathway to tetrahydrotyrosine in
Bacillus subtilis. Biochemistry 49 (2010) 912–923. [PMID: 20052993]
Parker, J.B. and Walsh, C.T. Olefin isomerization regiochemistries during tandem action of BacA and BacB on prephenate in bacilysin biosynthesis.
Biochemistry 51 (2012) 3241–3251. [PMID: 22483065]
Parker, J.B. and Walsh, C.T. Action and timing of BacC and BacD in the late stages of biosynthesis of the dipeptide antibiotic bacilysin.
Biochemistry 52 (2013) 889–901. [PMID: 23317005]
[EC 22.214.171.124 created 2015]
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