ExplorEnz: EC 5.3.1.32

Your query returned 1 entry. Printable version

5.3.1.32

Accepted name:

(4S)-4-hydroxy-5-phosphooxypentane-2,3-dione isomerase

Reaction:

(2S)-2-hydroxy-3,4-dioxopentyl phosphate = 3-hydroxy-2,4-dioxopentyl phosphate

Glossary:

(2S)-2-hydroxy-3,4-dioxopentyl phosphate = (4S)-4-hydroxy-5-phosphooxypentane-2,3-dione
(4S)-4,5-dihydroxypentane-2,3-dione = autoinducer 2 = AI-2

Other name(s):

lsrG (gene name); phospho-AI-2 isomerase; (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione aldose-ketose-isomerase; (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase; (4S)-4-hydroxy-5-phosphooxypentane-2,3-dione aldose-ketose-isomerase

Systematic name:

(2S)-2-hydroxy-3,4-dioxopentyl phosphate aldose-ketose-isomerase

Comments:

The enzyme participates in a degradation pathway of the bacterial quorum-sensing autoinducer molecule AI-2.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Xavier, K.B., Miller, S.T., Lu, W., Kim, J.H., Rabinowitz, J., Pelczer, I., Semmelhack, M.F. and Bassler, B.L. Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria. ACS Chem. Biol. 2 (2007) 128–136. [DOI] [PMID: 17274596]
2.	Marques, J.C., Lamosa, P., Russell, C., Ventura, R., Maycock, C., Semmelhack, M.F., Miller, S.T. and Xavier, K.B. Processing the interspecies quorum-sensing signal autoinducer-2 (AI-2): characterization of phospho-(S)-4,5-dihydroxy-2,3-pentanedione isomerization by LsrG protein. J. Biol. Chem. 286 (2011) 18331–18343. [DOI] [PMID: 21454635]

[EC 5.3.1.32 created 2015]