ExplorEnz: EC 5.2.1.13

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5.2.1.13

Accepted name:

prolycopene isomerase

Reaction:

7,9,7′,9′-tetracis-lycopene = all-trans-lycopene

For diagram of plant and cyanobacteria carotenoid biosynthesis, click here

Glossary:

prolycopene = 7,9,7′,9′-tetracis-lycopene

Other name(s):

CRTISO; carotene cis-trans isomerase; ZEBRA2 (gene name); carotene isomerase; carotenoid isomerase

Systematic name:

7,9,7′,9′-tetracis-lycopene cis-trans-isomerase

Comments:

Requires FADH₂ [1]. The enzyme is involved in carotenoid biosynthesis.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Yu, Q., Ghisla, S., Hirschberg, J., Mann, V. and Beyer, P. Plant carotene cis-trans isomerase CRTISO: a new member of the FADred-dependent flavoproteins catalyzing non-redox reactions. J. Biol. Chem. 286 (2011) 8666–8676. [DOI] [PMID: 21209101]
2.	Li, Q., Farre, G., Naqvi, S., Breitenbach, J., Sanahuja, G., Bai, C., Sandmann, G., Capell, T., Christou, P. and Zhu, C. Cloning and functional characterization of the maize carotenoid isomerase and β-carotene hydroxylase genes and their regulation during endosperm maturation. Transgenic Res. 19 (2010) 1053–1068. [DOI] [PMID: 20221689]
3.	Isaacson, T., Ronen, G., Zamir, D. and Hirschberg, J. Cloning of tangerine from tomato reveals a carotenoid isomerase essential for the production of β-carotene and xanthophylls in plants. Plant Cell 14 (2002) 333–342. [DOI] [PMID: 11884678]
4.	Chai, C., Fang, J., Liu, Y., Tong, H., Gong, Y., Wang, Y., Liu, M., Wang, Y., Qian, Q., Cheng, Z. and Chu, C. ZEBRA2, encoding a carotenoid isomerase, is involved in photoprotection in rice. Plant Mol. Biol. 75 (2011) 211–221. [DOI] [PMID: 21161331]

[EC 5.2.1.13 created 2011]