The Enzyme Database

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Accepted name: prolycopene isomerase
Reaction: 7,9,7′,9′-tetracis-lycopene = all-trans-lycopene
For diagram of plant and cyanobacteria carotenoid biosynthesis, click here
Glossary: prolycopene = 7,9,7′,9′-tetracis-lycopene
Other name(s): CRTISO; carotene cis-trans isomerase; ZEBRA2 (gene name); carotene isomerase; carotenoid isomerase
Systematic name: 7,9,7′,9′-tetracis-lycopene cis-trans-isomerase
Comments: Requires FADH2 [1]. The enzyme is involved in carotenoid biosynthesis.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Yu, Q., Ghisla, S., Hirschberg, J., Mann, V. and Beyer, P. Plant carotene cis-trans isomerase CRTISO: a new member of the FADred-dependent flavoproteins catalyzing non-redox reactions. J. Biol. Chem. 286 (2011) 8666–8676. [PMID: 21209101]
2.  Li, Q., Farre, G., Naqvi, S., Breitenbach, J., Sanahuja, G., Bai, C., Sandmann, G., Capell, T., Christou, P. and Zhu, C. Cloning and functional characterization of the maize carotenoid isomerase and β-carotene hydroxylase genes and their regulation during endosperm maturation. Transgenic Res. 19 (2010) 1053–1068. [PMID: 20221689]
3.  Isaacson, T., Ronen, G., Zamir, D. and Hirschberg, J. Cloning of tangerine from tomato reveals a carotenoid isomerase essential for the production of β-carotene and xanthophylls in plants. Plant Cell 14 (2002) 333–342. [PMID: 11884678]
4.  Chai, C., Fang, J., Liu, Y., Tong, H., Gong, Y., Wang, Y., Liu, M., Wang, Y., Qian, Q., Cheng, Z. and Chu, C. ZEBRA2, encoding a carotenoid isomerase, is involved in photoprotection in rice. Plant Mol. Biol. 75 (2011) 211–221. [PMID: 21161331]
[EC created 2011]

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