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Your query returned 1 entry. Printable version
EC | 5.1.3.18 | ||||||||||
Accepted name: | GDP-mannose 3,5-epimerase | ||||||||||
Reaction: | (1) GDP-α-D-mannose = GDP-β-L-galactose (2) GDP-α-D-mannose = GDP-β-L-gulose |
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Other name(s): | GME (gene name); GDP-D-mannose:GDP-L-galactose epimerase; guanosine 5′-diphosphate D-mannose:guanosine 5′-diphosphate L-galactose epimerase | ||||||||||
Systematic name: | GDP-α-D-mannose 3,5-epimerase | ||||||||||
Comments: | The enzyme catalyses the formation of the stable intermediate GDP-β-L-gulose as well as GDP-β-L-galactose. The reaction proceeds by C4′ oxidation of GDP-α-D-mannose followed by epimerization of the C5′ position to give GDP-β-L-4-dehydro-gulose. This intermediate is either reduced to give GDP-β-L-gulose or the C3′ position is epimerized to give GDP-β-L-4-dehydro-galactose, followed by C4′ reduction to yield GDP-β-L-galactose. Both products serve as intermediates in two different variants of plant L-ascorbate biosynthesis pathways. | ||||||||||
Links to other databases: | BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 72162-82-4 | ||||||||||
References: |
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